Petasites japonicus ethanol extract inhibited collagen-induced platelet aggregation and thrombus formation in rats

Hyun Dong Ji; Taddesse Yayeh; Ji Young Park; Sung Dae Kim; Eun Ju Im; Bo Ra Jeon; Joo Young Lee; Jin Kyu Park; Seung Bok Hong; Jin Yong Choi; Man Hee Rhee

Petasites japonicus ethanol extract inhibited collagen-induced platelet aggregation and thrombus formation in rats

Hyun Dong Ji, Taddesse Yayeh, Ji Young Park, Sung Dae Kim, Eun Ju Im, Bo Ra Jeon, Joo Young Lee, Jin Kyu Park, Seung Bok Hong, Jin Yong Choi, Man Hee Rhee

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Petasites japonicus (P. japonicus), a perennial plant of Asteraceae family, has been reported for antioxidant, anti-obesity and anti-allergic effects. However, the anti-platelet and anti-thrombotic activities of this plant were remained unclear. Therefore, this study aimed to portray the anti-platelet and anti-thrombotic properties of P. japonicus ethanol extract (PJET) in rats. PJET (31 -500 μg/ml) impaired in vitro collagen-stimulated platelet aggregation, [Ca²⁺] i mobilization and ATP secretion dose dependently. Moreover, PJET attenuated p38 mitogen-activated protein kinase, c-Jun N-terminal kinase 1 (JNK1) and extracellular-signalregulated protein kinase 2 (ERK2) protein phosphorylations. Likewise, PJET diminished thrombus formation in extracorporeal shunt model. In conclusion, PJET could be a source of potential natural compounds that reduce disseminated intravascular platelet aggregation and thrombus formation.

Original language	English
Pages (from-to)	360-369
Number of pages	10
Journal	Chiang Mai Journal of Science
Volume	41
Issue number	2
State	Published - 2014

Keywords

Mitogen-activated protein kinases
Petasites japonicus
Platelet aggregation
Thrombus formation

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Petasites japonicus ethanol extract inhibited collagen-induced platelet aggregation and thrombus formation in rats",

abstract = "Petasites japonicus (P. japonicus), a perennial plant of Asteraceae family, has been reported for antioxidant, anti-obesity and anti-allergic effects. However, the anti-platelet and anti-thrombotic activities of this plant were remained unclear. Therefore, this study aimed to portray the anti-platelet and anti-thrombotic properties of P. japonicus ethanol extract (PJET) in rats. PJET (31 -500 μg/ml) impaired in vitro collagen-stimulated platelet aggregation, [Ca2+] i mobilization and ATP secretion dose dependently. Moreover, PJET attenuated p38 mitogen-activated protein kinase, c-Jun N-terminal kinase 1 (JNK1) and extracellular-signalregulated protein kinase 2 (ERK2) protein phosphorylations. Likewise, PJET diminished thrombus formation in extracorporeal shunt model. In conclusion, PJET could be a source of potential natural compounds that reduce disseminated intravascular platelet aggregation and thrombus formation.",

keywords = "Mitogen-activated protein kinases, Petasites japonicus, Platelet aggregation, Thrombus formation",

author = "Ji, {Hyun Dong} and Taddesse Yayeh and Park, {Ji Young} and Kim, {Sung Dae} and Im, {Eun Ju} and Jeon, {Bo Ra} and Lee, {Joo Young} and Park, {Jin Kyu} and Hong, {Seung Bok} and Choi, {Jin Yong} and Rhee, {Man Hee}",

year = "2014",

language = "English",

volume = "41",

pages = "360--369",

journal = "Chiang Mai Journal of Science",

issn = "0125-2526",

publisher = "Chiang Mai University",

number = "2",

}

TY - JOUR

T1 - Petasites japonicus ethanol extract inhibited collagen-induced platelet aggregation and thrombus formation in rats

AU - Ji, Hyun Dong

AU - Yayeh, Taddesse

AU - Park, Ji Young

AU - Kim, Sung Dae

AU - Im, Eun Ju

AU - Jeon, Bo Ra

AU - Lee, Joo Young

AU - Park, Jin Kyu

AU - Hong, Seung Bok

AU - Choi, Jin Yong

AU - Rhee, Man Hee

PY - 2014

Y1 - 2014

N2 - Petasites japonicus (P. japonicus), a perennial plant of Asteraceae family, has been reported for antioxidant, anti-obesity and anti-allergic effects. However, the anti-platelet and anti-thrombotic activities of this plant were remained unclear. Therefore, this study aimed to portray the anti-platelet and anti-thrombotic properties of P. japonicus ethanol extract (PJET) in rats. PJET (31 -500 μg/ml) impaired in vitro collagen-stimulated platelet aggregation, [Ca2+] i mobilization and ATP secretion dose dependently. Moreover, PJET attenuated p38 mitogen-activated protein kinase, c-Jun N-terminal kinase 1 (JNK1) and extracellular-signalregulated protein kinase 2 (ERK2) protein phosphorylations. Likewise, PJET diminished thrombus formation in extracorporeal shunt model. In conclusion, PJET could be a source of potential natural compounds that reduce disseminated intravascular platelet aggregation and thrombus formation.

AB - Petasites japonicus (P. japonicus), a perennial plant of Asteraceae family, has been reported for antioxidant, anti-obesity and anti-allergic effects. However, the anti-platelet and anti-thrombotic activities of this plant were remained unclear. Therefore, this study aimed to portray the anti-platelet and anti-thrombotic properties of P. japonicus ethanol extract (PJET) in rats. PJET (31 -500 μg/ml) impaired in vitro collagen-stimulated platelet aggregation, [Ca2+] i mobilization and ATP secretion dose dependently. Moreover, PJET attenuated p38 mitogen-activated protein kinase, c-Jun N-terminal kinase 1 (JNK1) and extracellular-signalregulated protein kinase 2 (ERK2) protein phosphorylations. Likewise, PJET diminished thrombus formation in extracorporeal shunt model. In conclusion, PJET could be a source of potential natural compounds that reduce disseminated intravascular platelet aggregation and thrombus formation.

KW - Mitogen-activated protein kinases

KW - Petasites japonicus

KW - Platelet aggregation

KW - Thrombus formation

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M3 - Article

AN - SCOPUS:84899647167

SN - 0125-2526

VL - 41

SP - 360

EP - 369

JO - Chiang Mai Journal of Science

JF - Chiang Mai Journal of Science

IS - 2

ER -

Petasites japonicus ethanol extract inhibited collagen-induced platelet aggregation and thrombus formation in rats

Abstract

Keywords

UN SDGs

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