pH-sensitive fluorescent deoxyuridines labeled with 2-aminofluorene derivatives

Ji Won Lee; Ye seul Son; Jung Yean Lee; Mi Hyun Kim; Sang Keun Woo; Kyo Chul Lee; Yong Jin Lee; Gil Tae Hwang

doi:10.1016/j.tet.2016.07.049

pH-sensitive fluorescent deoxyuridines labeled with 2-aminofluorene derivatives

Ji Won Lee
, Ye seul Son
, Jung Yean Lee
, Mi Hyun Kim
, Sang Keun Woo
, Kyo Chul Lee
, Yong Jin Lee
, Gil Tae Hwang

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Two fluorescent 2′-deoxyuridines, U^AFand U^DAF, labeled with 2-aminofluorene and 2-dimethylaminofluorene units, respectively, and having values of pK_aof 4.27 and 4.66, respectively, display ‘turn-on’ emission responses in acidic solutions. They can also penetrate into HeLa cell membranes, where they exhibit their strong fluorescence under acidic conditions.

Original language	English
Pages (from-to)	5595-5601
Number of pages	7
Journal	Tetrahedron
Volume	72
Issue number	36
DOIs	https://doi.org/10.1016/j.tet.2016.07.049
State	Published - 2016

Keywords

Deoxyuridine
Fluorene
Fluorescence
Fluorescent probes
Nucleosides

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10.1016/j.tet.2016.07.049

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@article{cfb19268c6e74511a293ed403a7f7465,

title = "pH-sensitive fluorescent deoxyuridines labeled with 2-aminofluorene derivatives",

abstract = "Two fluorescent 2′-deoxyuridines, UAFand UDAF, labeled with 2-aminofluorene and 2-dimethylaminofluorene units, respectively, and having values of pKaof 4.27 and 4.66, respectively, display {\textquoteleft}turn-on{\textquoteright} emission responses in acidic solutions. They can also penetrate into HeLa cell membranes, where they exhibit their strong fluorescence under acidic conditions.",

keywords = "Deoxyuridine, Fluorene, Fluorescence, Fluorescent probes, Nucleosides",

author = "Lee, \{Ji Won\} and Son, \{Ye seul\} and Lee, \{Jung Yean\} and Kim, \{Mi Hyun\} and Woo, \{Sang Keun\} and Lee, \{Kyo Chul\} and Lee, \{Yong Jin\} and Hwang, \{Gil Tae\}",

note = "Publisher Copyright: {\textcopyright} 2016 Elsevier Ltd",

year = "2016",

doi = "10.1016/j.tet.2016.07.049",

language = "English",

volume = "72",

pages = "5595--5601",

journal = "Tetrahedron",

issn = "0040-4020",

publisher = "Elsevier Ltd.",

number = "36",

}

TY - JOUR

T1 - pH-sensitive fluorescent deoxyuridines labeled with 2-aminofluorene derivatives

AU - Lee, Ji Won

AU - Son, Ye seul

AU - Lee, Jung Yean

AU - Kim, Mi Hyun

AU - Woo, Sang Keun

AU - Lee, Kyo Chul

AU - Lee, Yong Jin

AU - Hwang, Gil Tae

PY - 2016

Y1 - 2016

N2 - Two fluorescent 2′-deoxyuridines, UAFand UDAF, labeled with 2-aminofluorene and 2-dimethylaminofluorene units, respectively, and having values of pKaof 4.27 and 4.66, respectively, display ‘turn-on’ emission responses in acidic solutions. They can also penetrate into HeLa cell membranes, where they exhibit their strong fluorescence under acidic conditions.

AB - Two fluorescent 2′-deoxyuridines, UAFand UDAF, labeled with 2-aminofluorene and 2-dimethylaminofluorene units, respectively, and having values of pKaof 4.27 and 4.66, respectively, display ‘turn-on’ emission responses in acidic solutions. They can also penetrate into HeLa cell membranes, where they exhibit their strong fluorescence under acidic conditions.

KW - Deoxyuridine

KW - Fluorene

KW - Fluorescence

KW - Fluorescent probes

KW - Nucleosides

UR - https://www.scopus.com/pages/publications/84981288339

U2 - 10.1016/j.tet.2016.07.049

DO - 10.1016/j.tet.2016.07.049

M3 - Article

AN - SCOPUS:84981288339

SN - 0040-4020

VL - 72

SP - 5595

EP - 5601

JO - Tetrahedron

JF - Tetrahedron

IS - 36

ER -

pH-sensitive fluorescent deoxyuridines labeled with 2-aminofluorene derivatives

Abstract

Keywords

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