Pharmacokinetics of a florfenicol-tylosin combination after intravenous and intramuscular administration to beagle dogs

E. Y. Kim; Elias Gebru; J. S. Lee; J. C. Kim; S. C. Park

doi:10.1292/jvms.10-0243

Pharmacokinetics of a florfenicol-tylosin combination after intravenous and intramuscular administration to beagle dogs

E. Y. Kim, Elias Gebru, J. S. Lee, J. C. Kim, S. C. Park

Department of Veterinary Medicine

Research output: Contribution to journal › Comment/debate

13 Scopus citations

Abstract

A pharmacokinetic study of a commercial florfenicol-tylosin (2:1) combination product was conducted in six beagle dogs after intravenous (IV) and intramuscular (IM) administration at doses of 10 mg/kg (florfenicol) and 5 mg/kg (tylosin). Serum drug concentrations were determined by a validated high performance liquid chromatography (HPLC) using UV detection. A rapid and nearly complete absorption of both drugs with a mean IM bioavailability of 103.9% (florfenicol) and 92.6% (tylosin), prolonged elimination halflife, and high tissue penetration with steady state volume of distribution of 2.63 l/kg (florfenicol) and 1.98 l/kg (tylosin) were observed. Additional studies, including pharmacodynamic and toxicological evaluation are required before recommendations can be made regarding the clinical application of the product in dogs.

Original language	English
Pages (from-to)	463-466
Number of pages	4
Journal	Journal of Veterinary Medical Science
Volume	73
Issue number	4
DOIs	https://doi.org/10.1292/jvms.10-0243
State	Published - Apr 2011

Keywords

Canine
Combination
Florfenicol
Pharmacokinetics
Tylosin

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title = "Pharmacokinetics of a florfenicol-tylosin combination after intravenous and intramuscular administration to beagle dogs",

abstract = "A pharmacokinetic study of a commercial florfenicol-tylosin (2:1) combination product was conducted in six beagle dogs after intravenous (IV) and intramuscular (IM) administration at doses of 10 mg/kg (florfenicol) and 5 mg/kg (tylosin). Serum drug concentrations were determined by a validated high performance liquid chromatography (HPLC) using UV detection. A rapid and nearly complete absorption of both drugs with a mean IM bioavailability of 103.9% (florfenicol) and 92.6% (tylosin), prolonged elimination halflife, and high tissue penetration with steady state volume of distribution of 2.63 l/kg (florfenicol) and 1.98 l/kg (tylosin) were observed. Additional studies, including pharmacodynamic and toxicological evaluation are required before recommendations can be made regarding the clinical application of the product in dogs.",

keywords = "Canine, Combination, Florfenicol, Pharmacokinetics, Tylosin",

author = "Kim, {E. Y.} and Elias Gebru and Lee, {J. S.} and Kim, {J. C.} and Park, {S. C.}",

year = "2011",

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doi = "10.1292/jvms.10-0243",

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TY - JOUR

T1 - Pharmacokinetics of a florfenicol-tylosin combination after intravenous and intramuscular administration to beagle dogs

AU - Kim, E. Y.

AU - Gebru, Elias

AU - Lee, J. S.

AU - Kim, J. C.

AU - Park, S. C.

PY - 2011/4

Y1 - 2011/4

N2 - A pharmacokinetic study of a commercial florfenicol-tylosin (2:1) combination product was conducted in six beagle dogs after intravenous (IV) and intramuscular (IM) administration at doses of 10 mg/kg (florfenicol) and 5 mg/kg (tylosin). Serum drug concentrations were determined by a validated high performance liquid chromatography (HPLC) using UV detection. A rapid and nearly complete absorption of both drugs with a mean IM bioavailability of 103.9% (florfenicol) and 92.6% (tylosin), prolonged elimination halflife, and high tissue penetration with steady state volume of distribution of 2.63 l/kg (florfenicol) and 1.98 l/kg (tylosin) were observed. Additional studies, including pharmacodynamic and toxicological evaluation are required before recommendations can be made regarding the clinical application of the product in dogs.

AB - A pharmacokinetic study of a commercial florfenicol-tylosin (2:1) combination product was conducted in six beagle dogs after intravenous (IV) and intramuscular (IM) administration at doses of 10 mg/kg (florfenicol) and 5 mg/kg (tylosin). Serum drug concentrations were determined by a validated high performance liquid chromatography (HPLC) using UV detection. A rapid and nearly complete absorption of both drugs with a mean IM bioavailability of 103.9% (florfenicol) and 92.6% (tylosin), prolonged elimination halflife, and high tissue penetration with steady state volume of distribution of 2.63 l/kg (florfenicol) and 1.98 l/kg (tylosin) were observed. Additional studies, including pharmacodynamic and toxicological evaluation are required before recommendations can be made regarding the clinical application of the product in dogs.

KW - Canine

KW - Combination

KW - Florfenicol

KW - Pharmacokinetics

KW - Tylosin

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SN - 0916-7250

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JO - Journal of Veterinary Medical Science

JF - Journal of Veterinary Medical Science

IS - 4

ER -

Pharmacokinetics of a florfenicol-tylosin combination after intravenous and intramuscular administration to beagle dogs

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Keywords

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