Phenolic components from the leaves of Panax ginseng and their effects on HL-60 human leukemia cells

Nguyen Huu Tung; Jeong Hyun Son; Kyoungwon Cho; Jeong Ah Kim; Jae Hee Hyun; Hee Kyoung Kang; Gyu Yong Song; Chun Jung Park; Young Ho Kim

doi:10.1007/s10068-010-0040-z

Phenolic components from the leaves of Panax ginseng and their effects on HL-60 human leukemia cells

Nguyen Huu Tung, Jeong Hyun Son, Kyoungwon Cho, Jeong Ah Kim, Jae Hee Hyun, Hee Kyoung Kang, Gyu Yong Song, Chun Jung Park, Young Ho Kim

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

This study investigates phenolic components from the Panax ginseng C.A. Meyer leaves led to the isolation of 3 flavonoids (1-3). Their structures were characterized on the basis of physicochemical properties, nuclear magnetic resonance (NMR) spectra, electron spray ionization-mass spectrometry (ESI-MS) data, and comparison with those in the literature. Of them, sophoraflavonoloside (2) and prunin (3) were found to inhibit the growth of HL- 60 human leukemia cells with IC50 in values of 29.8 and 21.4 μM by the induction of apoptosis.

Original language	English
Pages (from-to)	271-274
Number of pages	4
Journal	Food Science and Biotechnology
Volume	19
Issue number	1
DOIs	https://doi.org/10.1007/s10068-010-0040-z
State	Published - Feb 2010

Keywords

Apoptosis
Araliaceae
Cytotoxic activity
Flavonoid
HL-60 cell
Panax ginseng

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10.1007/s10068-010-0040-z

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abstract = "This study investigates phenolic components from the Panax ginseng C.A. Meyer leaves led to the isolation of 3 flavonoids (1-3). Their structures were characterized on the basis of physicochemical properties, nuclear magnetic resonance (NMR) spectra, electron spray ionization-mass spectrometry (ESI-MS) data, and comparison with those in the literature. Of them, sophoraflavonoloside (2) and prunin (3) were found to inhibit the growth of HL- 60 human leukemia cells with IC50 in values of 29.8 and 21.4 μM by the induction of apoptosis.",

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AU - Tung, Nguyen Huu

AU - Son, Jeong Hyun

AU - Cho, Kyoungwon

AU - Kim, Jeong Ah

AU - Hyun, Jae Hee

AU - Kang, Hee Kyoung

AU - Song, Gyu Yong

AU - Park, Chun Jung

AU - Kim, Young Ho

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KW - Araliaceae

KW - Cytotoxic activity

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Phenolic components from the leaves of Panax ginseng and their effects on HL-60 human leukemia cells

Abstract

Keywords

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