Phenolic components from the leaves of Panax ginseng and their effects on HL-60 human leukemia cells

Nguyen Huu Tung; Jeong Hyun Son; Kyoungwon Cho; Jeong Ah Kim; Jae Hee Hyun; Hee Kyoung Kang; Gyu Yong Song; Chun Jung Park; Young Ho Kim

doi:10.1007/s10068-010-0040-z

Phenolic components from the leaves of Panax ginseng and their effects on HL-60 human leukemia cells

Nguyen Huu Tung
, Jeong Hyun Son
, Kyoungwon Cho
, Jeong Ah Kim
, Jae Hee Hyun
, Hee Kyoung Kang
, Gyu Yong Song
, Chun Jung Park
, Young Ho Kim

Chungnam National University
Jeju National University
Geumsan Ginseng Cooperative Association

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

This study investigates phenolic components from the Panax ginseng C.A. Meyer leaves led to the isolation of 3 flavonoids (1-3). Their structures were characterized on the basis of physicochemical properties, nuclear magnetic resonance (NMR) spectra, electron spray ionization-mass spectrometry (ESI-MS) data, and comparison with those in the literature. Of them, sophoraflavonoloside (2) and prunin (3) were found to inhibit the growth of HL- 60 human leukemia cells with IC50 in values of 29.8 and 21.4 μM by the induction of apoptosis.

Original language	English
Pages (from-to)	271-274
Number of pages	4
Journal	Food Science and Biotechnology
Volume	19
Issue number	1
DOIs	https://doi.org/10.1007/s10068-010-0040-z
State	Published - Feb 2010

Keywords

Apoptosis
Araliaceae
Cytotoxic activity
Flavonoid
HL-60 cell
Panax ginseng

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10.1007/s10068-010-0040-z

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abstract = "This study investigates phenolic components from the Panax ginseng C.A. Meyer leaves led to the isolation of 3 flavonoids (1-3). Their structures were characterized on the basis of physicochemical properties, nuclear magnetic resonance (NMR) spectra, electron spray ionization-mass spectrometry (ESI-MS) data, and comparison with those in the literature. Of them, sophoraflavonoloside (2) and prunin (3) were found to inhibit the growth of HL- 60 human leukemia cells with IC50 in values of 29.8 and 21.4 μM by the induction of apoptosis.",

keywords = "Apoptosis, Araliaceae, Cytotoxic activity, Flavonoid, HL-60 cell, Panax ginseng",

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year = "2010",

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doi = "10.1007/s10068-010-0040-z",

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T1 - Phenolic components from the leaves of Panax ginseng and their effects on HL-60 human leukemia cells

AU - Tung, Nguyen Huu

AU - Son, Jeong Hyun

AU - Cho, Kyoungwon

AU - Kim, Jeong Ah

AU - Hyun, Jae Hee

AU - Kang, Hee Kyoung

AU - Song, Gyu Yong

AU - Park, Chun Jung

AU - Kim, Young Ho

PY - 2010/2

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N2 - This study investigates phenolic components from the Panax ginseng C.A. Meyer leaves led to the isolation of 3 flavonoids (1-3). Their structures were characterized on the basis of physicochemical properties, nuclear magnetic resonance (NMR) spectra, electron spray ionization-mass spectrometry (ESI-MS) data, and comparison with those in the literature. Of them, sophoraflavonoloside (2) and prunin (3) were found to inhibit the growth of HL- 60 human leukemia cells with IC50 in values of 29.8 and 21.4 μM by the induction of apoptosis.

AB - This study investigates phenolic components from the Panax ginseng C.A. Meyer leaves led to the isolation of 3 flavonoids (1-3). Their structures were characterized on the basis of physicochemical properties, nuclear magnetic resonance (NMR) spectra, electron spray ionization-mass spectrometry (ESI-MS) data, and comparison with those in the literature. Of them, sophoraflavonoloside (2) and prunin (3) were found to inhibit the growth of HL- 60 human leukemia cells with IC50 in values of 29.8 and 21.4 μM by the induction of apoptosis.

KW - Apoptosis

KW - Araliaceae

KW - Cytotoxic activity

KW - Flavonoid

KW - HL-60 cell

KW - Panax ginseng

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DO - 10.1007/s10068-010-0040-z

M3 - Article

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SN - 1226-7708

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SP - 271

EP - 274

JO - Food Science and Biotechnology

JF - Food Science and Biotechnology

IS - 1

ER -

Phenolic components from the leaves of Panax ginseng and their effects on HL-60 human leukemia cells

Abstract

Keywords

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