Phenolic compounds from Artemisia iwayomogi and their effects on osteoblastic MC3T3-E1 cells

Yan Ding; Chun Liang; Seo Young Yang; Jeong Chan Ra; Eun Mi Choi; Jeong Ah Kim; Young Ho Kim

doi:10.1248/bpb.33.1448

Phenolic compounds from Artemisia iwayomogi and their effects on osteoblastic MC3T3-E1 cells

Yan Ding, Chun Liang, Seo Young Yang, Jeong Chan Ra, Eun Mi Choi, Jeong Ah Kim, Young Ho Kim

Research output: Contribution to journal › Comment/debate

20 Scopus citations

Abstract

One new (4) and twelve known phenolic compounds (1-3, 5-13) were isolated from a 70% MeOH extract of the aerial parts of Artemisia iwayomogi. The new compound was identified as 7,8-dimethoxy-coumarin-9-O-(6'-O-(E)-coumaroyl)-β-D-glucopyranoside (4) and named iwayomin. The effects of compounds 1-13 on the function of osteoblastic MC3T3-E1 cells were examined by evaluating cell viability, alkaline phosphatase (ALP) activity, collagen synthesis, and mineralization in the presence of each compound. Compounds 3, 4, 7, and 9 showed potential in stimulating osteoblastic bone formation and may be useful for the prevention and/or treatment of osteoporosis.

Original language	English
Pages (from-to)	1448-1453
Number of pages	6
Journal	Biological and Pharmaceutical Bulletin
Volume	33
Issue number	8
DOIs	https://doi.org/10.1248/bpb.33.1448
State	Published - 2010

Keywords

Artemisia iwayomogi
Iwayomin
Osteoblastic MC3T3-E1 cell
Phenolic compound

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10.1248/bpb.33.1448

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title = "Phenolic compounds from Artemisia iwayomogi and their effects on osteoblastic MC3T3-E1 cells",

abstract = "One new (4) and twelve known phenolic compounds (1-3, 5-13) were isolated from a 70% MeOH extract of the aerial parts of Artemisia iwayomogi. The new compound was identified as 7,8-dimethoxy-coumarin-9-O-(6'-O-(E)-coumaroyl)-β-D-glucopyranoside (4) and named iwayomin. The effects of compounds 1-13 on the function of osteoblastic MC3T3-E1 cells were examined by evaluating cell viability, alkaline phosphatase (ALP) activity, collagen synthesis, and mineralization in the presence of each compound. Compounds 3, 4, 7, and 9 showed potential in stimulating osteoblastic bone formation and may be useful for the prevention and/or treatment of osteoporosis.",

keywords = "Artemisia iwayomogi, Iwayomin, Osteoblastic MC3T3-E1 cell, Phenolic compound",

author = "Yan Ding and Chun Liang and Yang, {Seo Young} and Ra, {Jeong Chan} and Choi, {Eun Mi} and Kim, {Jeong Ah} and {Ho Kim}, Young",

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doi = "10.1248/bpb.33.1448",

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journal = "Biological and Pharmaceutical Bulletin",

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TY - JOUR

T1 - Phenolic compounds from Artemisia iwayomogi and their effects on osteoblastic MC3T3-E1 cells

AU - Ding, Yan

AU - Liang, Chun

AU - Yang, Seo Young

AU - Ra, Jeong Chan

AU - Choi, Eun Mi

AU - Kim, Jeong Ah

AU - Ho Kim, Young

PY - 2010

Y1 - 2010

N2 - One new (4) and twelve known phenolic compounds (1-3, 5-13) were isolated from a 70% MeOH extract of the aerial parts of Artemisia iwayomogi. The new compound was identified as 7,8-dimethoxy-coumarin-9-O-(6'-O-(E)-coumaroyl)-β-D-glucopyranoside (4) and named iwayomin. The effects of compounds 1-13 on the function of osteoblastic MC3T3-E1 cells were examined by evaluating cell viability, alkaline phosphatase (ALP) activity, collagen synthesis, and mineralization in the presence of each compound. Compounds 3, 4, 7, and 9 showed potential in stimulating osteoblastic bone formation and may be useful for the prevention and/or treatment of osteoporosis.

AB - One new (4) and twelve known phenolic compounds (1-3, 5-13) were isolated from a 70% MeOH extract of the aerial parts of Artemisia iwayomogi. The new compound was identified as 7,8-dimethoxy-coumarin-9-O-(6'-O-(E)-coumaroyl)-β-D-glucopyranoside (4) and named iwayomin. The effects of compounds 1-13 on the function of osteoblastic MC3T3-E1 cells were examined by evaluating cell viability, alkaline phosphatase (ALP) activity, collagen synthesis, and mineralization in the presence of each compound. Compounds 3, 4, 7, and 9 showed potential in stimulating osteoblastic bone formation and may be useful for the prevention and/or treatment of osteoporosis.

KW - Artemisia iwayomogi

KW - Iwayomin

KW - Osteoblastic MC3T3-E1 cell

KW - Phenolic compound

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U2 - 10.1248/bpb.33.1448

DO - 10.1248/bpb.33.1448

M3 - Comment/debate

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AN - SCOPUS:77956131069

SN - 0918-6158

VL - 33

SP - 1448

EP - 1453

JO - Biological and Pharmaceutical Bulletin

JF - Biological and Pharmaceutical Bulletin

IS - 8

ER -

Phenolic compounds from Artemisia iwayomogi and their effects on osteoblastic MC3T3-E1 cells

Abstract

Keywords

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