Phosphonate Pendant Armed Propylene Cross-Bridged Cyclam: Synthesis and Evaluation as a Chelator for Cu-64

Nikunj Bhatt; Nisarg Soni; Yeong Su Ha; Woonghee Lee; Darpan N. Pandya; Swarbhanu Sarkar; Jung Young Kim; Hochun Lee; Sun Hee Kim; Gwang Il An; Jeongsoo Yoo

doi:10.1021/acsmedchemlett.5b00362

Phosphonate Pendant Armed Propylene Cross-Bridged Cyclam: Synthesis and Evaluation as a Chelator for Cu-64

Nikunj Bhatt, Nisarg Soni, Yeong Su Ha, Woonghee Lee, Darpan N. Pandya, Swarbhanu Sarkar, Jung Young Kim, Hochun Lee, Sun Hee Kim, Gwang Il An, Jeongsoo Yoo

Department of Medicine

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

A propylene cross-bridged macrocyclic chelator with two phosphonate pendant arms (PCB-TE2P) was synthesized from cyclam. Various properties of the synthesized chelator, including Cu-complexation, Cu-complex stability, ⁶⁴Cu-radiolabeling, and in vivo behavior, were studied and compared with those of a previously reported propylene cross-bridged chelator (PCB-TE2A).

Original language	English
Pages (from-to)	1162-1166
Number of pages	5
Journal	ACS Medicinal Chemistry Letters
Volume	6
Issue number	11
DOIs	https://doi.org/10.1021/acsmedchemlett.5b00362
State	Published - 20 Oct 2015

Keywords

Bifunctional chelator
phosphonate pendant arms
propylene cross bridge
radiopharmaceuticals

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10.1021/acsmedchemlett.5b00362

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title = "Phosphonate Pendant Armed Propylene Cross-Bridged Cyclam: Synthesis and Evaluation as a Chelator for Cu-64",

abstract = "A propylene cross-bridged macrocyclic chelator with two phosphonate pendant arms (PCB-TE2P) was synthesized from cyclam. Various properties of the synthesized chelator, including Cu-complexation, Cu-complex stability, 64Cu-radiolabeling, and in vivo behavior, were studied and compared with those of a previously reported propylene cross-bridged chelator (PCB-TE2A).",

keywords = "Bifunctional chelator, phosphonate pendant arms, propylene cross bridge, radiopharmaceuticals",

author = "Nikunj Bhatt and Nisarg Soni and Ha, \{Yeong Su\} and Woonghee Lee and Pandya, \{Darpan N.\} and Swarbhanu Sarkar and Kim, \{Jung Young\} and Hochun Lee and Kim, \{Sun Hee\} and An, \{Gwang Il\} and Jeongsoo Yoo",

note = "Publisher Copyright: {\textcopyright} 2015 American Chemical Society.",

year = "2015",

month = oct,

day = "20",

doi = "10.1021/acsmedchemlett.5b00362",

language = "English",

volume = "6",

pages = "1162--1166",

journal = "ACS Medicinal Chemistry Letters",

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publisher = "American Chemical Society",

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TY - JOUR

T1 - Phosphonate Pendant Armed Propylene Cross-Bridged Cyclam

T2 - Synthesis and Evaluation as a Chelator for Cu-64

AU - Bhatt, Nikunj

AU - Soni, Nisarg

AU - Ha, Yeong Su

AU - Lee, Woonghee

AU - Pandya, Darpan N.

AU - Sarkar, Swarbhanu

AU - Kim, Jung Young

AU - Lee, Hochun

AU - Kim, Sun Hee

AU - An, Gwang Il

AU - Yoo, Jeongsoo

PY - 2015/10/20

Y1 - 2015/10/20

N2 - A propylene cross-bridged macrocyclic chelator with two phosphonate pendant arms (PCB-TE2P) was synthesized from cyclam. Various properties of the synthesized chelator, including Cu-complexation, Cu-complex stability, 64Cu-radiolabeling, and in vivo behavior, were studied and compared with those of a previously reported propylene cross-bridged chelator (PCB-TE2A).

AB - A propylene cross-bridged macrocyclic chelator with two phosphonate pendant arms (PCB-TE2P) was synthesized from cyclam. Various properties of the synthesized chelator, including Cu-complexation, Cu-complex stability, 64Cu-radiolabeling, and in vivo behavior, were studied and compared with those of a previously reported propylene cross-bridged chelator (PCB-TE2A).

KW - Bifunctional chelator

KW - phosphonate pendant arms

KW - propylene cross bridge

KW - radiopharmaceuticals

UR - https://www.scopus.com/pages/publications/84947259180

U2 - 10.1021/acsmedchemlett.5b00362

DO - 10.1021/acsmedchemlett.5b00362

M3 - Article

AN - SCOPUS:84947259180

SN - 1948-5875

VL - 6

SP - 1162

EP - 1166

JO - ACS Medicinal Chemistry Letters

JF - ACS Medicinal Chemistry Letters

IS - 11

ER -

Phosphonate Pendant Armed Propylene Cross-Bridged Cyclam: Synthesis and Evaluation as a Chelator for Cu-64

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Keywords

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