Abstract
To formulate a self-nanoemulsifying drug delivery system (SNEDDS) for the oral administration of docetaxel as an alternative to commercial docetaxel-loaded injectable products, it was prepared by spray-drying an aqueous solution containing liquid SNEDDS and colloidal silica. Its physicochemical properties and oral bioavailability were investigated compared to a clear docetaxel solution administered intravenously or orally to rats. In the docetaxel-loaded solid SNEDDS prepared with colloidal silica, the liquid SNEDDS composed of Capryol 90, Cremophore EL and Transcutol HP (45/35/20, volume ratio) was absorbed inside the pores of carriers, and docetaxel was present in a changed amorphous state. The solid SNEDDS with 3.3% (w/v) docetaxel produced nanoemulsions, and showed about 12.5% absolute bioavailability in rats. Thus, this solid SNEDDS may be a potential candidate for oral pharmaceutical product with improved oral bioavailability of docetaxel.
Original language | English |
---|---|
Pages (from-to) | 307-314 |
Number of pages | 8 |
Journal | Journal of Microencapsulation |
Volume | 30 |
Issue number | 4 |
DOIs | |
State | Published - 2013 |
Keywords
- Absolute bioavailability
- Capryol 90
- Cremophore EL
- Docetaxel
- Solid self-nanoemulsifying drug delivery system
- Transcutol HP