Physicochemical characterization and in vivo evaluation of solid self-nanoemulsifying drug delivery system for oral administration of docetaxel

Qizhe Quan, Dong Wuk Kim, Nirmal Marasini, Dae Hwan Kim, Jin Ki Kim, Jong Oh Kim, Chul Soon Yong, Han Gon Choi

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

To formulate a self-nanoemulsifying drug delivery system (SNEDDS) for the oral administration of docetaxel as an alternative to commercial docetaxel-loaded injectable products, it was prepared by spray-drying an aqueous solution containing liquid SNEDDS and colloidal silica. Its physicochemical properties and oral bioavailability were investigated compared to a clear docetaxel solution administered intravenously or orally to rats. In the docetaxel-loaded solid SNEDDS prepared with colloidal silica, the liquid SNEDDS composed of Capryol 90, Cremophore EL and Transcutol HP (45/35/20, volume ratio) was absorbed inside the pores of carriers, and docetaxel was present in a changed amorphous state. The solid SNEDDS with 3.3% (w/v) docetaxel produced nanoemulsions, and showed about 12.5% absolute bioavailability in rats. Thus, this solid SNEDDS may be a potential candidate for oral pharmaceutical product with improved oral bioavailability of docetaxel.

Original languageEnglish
Pages (from-to)307-314
Number of pages8
JournalJournal of Microencapsulation
Volume30
Issue number4
DOIs
StatePublished - 2013

Keywords

  • Absolute bioavailability
  • Capryol 90
  • Cremophore EL
  • Docetaxel
  • Solid self-nanoemulsifying drug delivery system
  • Transcutol HP

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