Physiological activities of a β-glucan produced by Panebacillus polymyxa

Hee Kyoung Jung; Seung Chun Park; Byung Kwon Park; Joo Heon Hong

doi:10.1007/s10529-008-9732-3

Physiological activities of a β-glucan produced by Panebacillus polymyxa

Hee Kyoung Jung, Seung Chun Park, Byung Kwon Park, Joo Heon Hong

Department of Veterinary Medicine

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

In vitro bioactivities of a β-glucan produced by Panebacillus polymyxa JB115 were investigated. Nitric oxide production by RAW 264.7 macrophage cells pre-treated with β-glucan JB115 (from 0.1 to 1 mg ml^-1) was significantly increased, compared to that in untreated cells (P < 0.001). The β-glucan JB115 increased superoxide radical-scavenging activity by 66% at 1 mg ml^-1. It also suppressed hyaluronidase (32%) and collagenase (33%) activities and, additionally, displayed antitumor activity, blocking the growth of Sarcoma 180 cells in a concentration-dependent manner. The immune-stimulatory, antioxidant, collagenase inhibitory and hyaluronidase inhibitory effects of the β-glucan support its potential role in the prevention of bacterial disease against fish and in the protection of skin against aging.

Original language	English
Pages (from-to)	1545-1551
Number of pages	7
Journal	Biotechnology Letters
Volume	30
Issue number	9
DOIs	https://doi.org/10.1007/s10529-008-9732-3
State	Published - Sep 2008

Keywords

β-glucan
Antitumor activity
Collagenase activity
Hyaluronidase activity
Panebacillus polymyxa

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10.1007/s10529-008-9732-3

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title = "Physiological activities of a β-glucan produced by Panebacillus polymyxa",

abstract = "In vitro bioactivities of a β-glucan produced by Panebacillus polymyxa JB115 were investigated. Nitric oxide production by RAW 264.7 macrophage cells pre-treated with β-glucan JB115 (from 0.1 to 1 mg ml-1) was significantly increased, compared to that in untreated cells (P < 0.001). The β-glucan JB115 increased superoxide radical-scavenging activity by 66% at 1 mg ml-1. It also suppressed hyaluronidase (32%) and collagenase (33%) activities and, additionally, displayed antitumor activity, blocking the growth of Sarcoma 180 cells in a concentration-dependent manner. The immune-stimulatory, antioxidant, collagenase inhibitory and hyaluronidase inhibitory effects of the β-glucan support its potential role in the prevention of bacterial disease against fish and in the protection of skin against aging.",

keywords = "β-glucan, Antitumor activity, Collagenase activity, Hyaluronidase activity, Panebacillus polymyxa",

author = "Jung, {Hee Kyoung} and Park, {Seung Chun} and Park, {Byung Kwon} and Hong, {Joo Heon}",

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T1 - Physiological activities of a β-glucan produced by Panebacillus polymyxa

AU - Jung, Hee Kyoung

AU - Park, Seung Chun

AU - Park, Byung Kwon

AU - Hong, Joo Heon

PY - 2008/9

Y1 - 2008/9

N2 - In vitro bioactivities of a β-glucan produced by Panebacillus polymyxa JB115 were investigated. Nitric oxide production by RAW 264.7 macrophage cells pre-treated with β-glucan JB115 (from 0.1 to 1 mg ml-1) was significantly increased, compared to that in untreated cells (P < 0.001). The β-glucan JB115 increased superoxide radical-scavenging activity by 66% at 1 mg ml-1. It also suppressed hyaluronidase (32%) and collagenase (33%) activities and, additionally, displayed antitumor activity, blocking the growth of Sarcoma 180 cells in a concentration-dependent manner. The immune-stimulatory, antioxidant, collagenase inhibitory and hyaluronidase inhibitory effects of the β-glucan support its potential role in the prevention of bacterial disease against fish and in the protection of skin against aging.

AB - In vitro bioactivities of a β-glucan produced by Panebacillus polymyxa JB115 were investigated. Nitric oxide production by RAW 264.7 macrophage cells pre-treated with β-glucan JB115 (from 0.1 to 1 mg ml-1) was significantly increased, compared to that in untreated cells (P < 0.001). The β-glucan JB115 increased superoxide radical-scavenging activity by 66% at 1 mg ml-1. It also suppressed hyaluronidase (32%) and collagenase (33%) activities and, additionally, displayed antitumor activity, blocking the growth of Sarcoma 180 cells in a concentration-dependent manner. The immune-stimulatory, antioxidant, collagenase inhibitory and hyaluronidase inhibitory effects of the β-glucan support its potential role in the prevention of bacterial disease against fish and in the protection of skin against aging.

KW - β-glucan

KW - Antitumor activity

KW - Collagenase activity

KW - Hyaluronidase activity

KW - Panebacillus polymyxa

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SP - 1545

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JF - Biotechnology Letters

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Physiological activities of a β-glucan produced by Panebacillus polymyxa

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Keywords

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