Plasmid-mediated quinolone resistance determinants qnrA, qnrB, and qnrS among clinical isolates of Enterobacteriaceae in a Korean hospital

Dorji Tamang Migma, Yong Seol Sung, Jae Young Oh, Young Kang Hee, Chul Lee Je, Chul Lee Yoo, Taek Cho Dong, Jungmin Kim

Research output: Contribution to journalArticlepeer-review

60 Scopus citations

Abstract

Screening of 368 consecutive nonreplicate clinical isolates of Enterobacteriaceae resistant to nalidixic acid and at least one extended-spectrum β-lactam revealed the presence of qnrA, qnrB, and qnrS determinants, and identified novel qnrB variants, in Citrobacter freundii isolates. This study also revealed, for the first time, the linkage of qnrB, armA, and extended-spectrum and/or AmpC-type β-lactamase genes on large conjugative plasmids.

Original languageEnglish
Pages (from-to)4159-4162
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume52
Issue number11
DOIs
StatePublished - Nov 2008

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