TY - JOUR
T1 - Poly(4-vinyl pyridine)-grafted graphene oxide for drug delivery and antimicrobial applications
AU - Kavitha, Thangavelu
AU - Kang, Inn Kyu
AU - Park, Soo Young
N1 - Publisher Copyright:
© 2015 Society of Chemical Industry.
PY - 2015/11/1
Y1 - 2015/11/1
N2 - Graphene oxide- poly (4-vinyl pyridine) (GO-P4VP) composite prepared by insitu atom transfer radical polymerization was investigated for drug delivery and antibacterial applications. Graphene oxide (GO) was covalently functionalized with poly(4-vinyl pyridine) (P4VP) by atom transfer radical polymerization for drug delivery and antimicrobial applications. The physiochemical properties, chemical structure, composition and morphology of the P4VP-functionalized GO (GO-P4VP) were studied. Simple physisorption of a cancer drug, camptothecin (CPT), via π - π stacking and/or hydrophobic interactions on the GO-P4VP was tested for drug loading and its release by altering the pH. The GO-P4VP has low cytotoxicity, and the CPT-loaded GO-P4VP exhibited a high potency for killing cancer cells in vitro. Prominent antimicrobial properties against Escherichia coli and Staphylococcus aureus were also observed. Thus, the GO-P4VP can be utilized as a drug delivery vector with high biocompatibility, solubility and stability in physiological solutions, a suitable payload capacity and excellent bacterial toxicity. Owing to its small size, low cost, large specific area, ready scalability and useful non-covalent interactions, GO-P4VP is a novel material for biomedical, industrial and environmental applications.
AB - Graphene oxide- poly (4-vinyl pyridine) (GO-P4VP) composite prepared by insitu atom transfer radical polymerization was investigated for drug delivery and antibacterial applications. Graphene oxide (GO) was covalently functionalized with poly(4-vinyl pyridine) (P4VP) by atom transfer radical polymerization for drug delivery and antimicrobial applications. The physiochemical properties, chemical structure, composition and morphology of the P4VP-functionalized GO (GO-P4VP) were studied. Simple physisorption of a cancer drug, camptothecin (CPT), via π - π stacking and/or hydrophobic interactions on the GO-P4VP was tested for drug loading and its release by altering the pH. The GO-P4VP has low cytotoxicity, and the CPT-loaded GO-P4VP exhibited a high potency for killing cancer cells in vitro. Prominent antimicrobial properties against Escherichia coli and Staphylococcus aureus were also observed. Thus, the GO-P4VP can be utilized as a drug delivery vector with high biocompatibility, solubility and stability in physiological solutions, a suitable payload capacity and excellent bacterial toxicity. Owing to its small size, low cost, large specific area, ready scalability and useful non-covalent interactions, GO-P4VP is a novel material for biomedical, industrial and environmental applications.
KW - Drug delivery
KW - Grafting
KW - Graphene oxide
KW - Poly(4-vinyl pyridine)
UR - http://www.scopus.com/inward/record.url?scp=84942835643&partnerID=8YFLogxK
U2 - 10.1002/pi.4968
DO - 10.1002/pi.4968
M3 - Article
AN - SCOPUS:84942835643
SN - 0959-8103
VL - 64
SP - 1660
EP - 1666
JO - Polymer International
JF - Polymer International
IS - 11
ER -