Polyaspartic acid-coated paramagnetic gadolinium oxide nanoparticles as a dual-modal t1 and t2 magnetic resonance imaging contrast agent

Shanti Marasini; Huan Yue; Adibehalsadat Ghazanfari; Son Long Ho; Ji Ae Park; Soyeon Kim; Hyunsil Cha; Shuwen Liu; Tirusew Tegafaw; Mohammad Yaseen Ahmad; Abdullah Khamis Ali Al Saidi; Dejun Zhao; Ying Liu; Kwon Seok Chae; Yongmin Chang; Gang Ho Lee

doi:10.3390/app11178222

Polyaspartic acid-coated paramagnetic gadolinium oxide nanoparticles as a dual-modal t₁ and t₂ magnetic resonance imaging contrast agent

Shanti Marasini, Huan Yue, Adibehalsadat Ghazanfari, Son Long Ho, Ji Ae Park, Soyeon Kim, Hyunsil Cha, Shuwen Liu, Tirusew Tegafaw, Mohammad Yaseen Ahmad, Abdullah Khamis Ali Al Saidi, Dejun Zhao, Ying Liu, Kwon Seok Chae, Yongmin Chang, Gang Ho Lee

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Surface-coating polymers contribute to nanoparticle-based magnetic resonance imaging (MRI) contrast agents because they can affect the relaxometric properties of the nanoparticles. In this study, polyaspartic acid (PASA)-coated ultrasmall Gd₂ O₃ nanoparticles with an average particle diameter of 2.0 nm were synthesized using the one-pot polyol method. The synthesized nanoparticles exhibited r₁ and r₂ of 19.1 and = 53.7 s⁻¹ mM⁻¹, respectively, (r₁ and r₂ are longitudinal and transverse water–proton spin relaxivities, respectively) at 3.0 T MR field, approximately 5 and 10 times higher than those of commercial Gd-chelate contrast agents, respectively. The T₁ and T₂ MR images could be obtained due to an appreciable r₂ /r₁ ratio of 2.80, indicating their potential as a dual-modal T₁ and T₂ MRI contrast agent.

Original language	English
Article number	8222
Journal	Applied Sciences (Switzerland)
Volume	11
Issue number	17
DOIs	https://doi.org/10.3390/app11178222
State	Published - Sep 2021

Keywords

Gadolinium oxide nanoparticle
Magnetic resonance imaging
Polyaspartic acid
T and T dual-modal imaging

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10.3390/app11178222

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Marasini, S., Yue, H., Ghazanfari, A., Ho, S. L., Park, J. A., Kim, S., Cha, H., Liu, S., Tegafaw, T., Ahmad, M. Y., Al Saidi, A. K. A., Zhao, D., Liu, Y., Chae, K. S., Chang, Y., & Lee, G. H. (2021). Polyaspartic acid-coated paramagnetic gadolinium oxide nanoparticles as a dual-modal t₁ and t₂ magnetic resonance imaging contrast agent. Applied Sciences (Switzerland), 11(17), Article 8222. https://doi.org/10.3390/app11178222

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title = "Polyaspartic acid-coated paramagnetic gadolinium oxide nanoparticles as a dual-modal t1 and t2 magnetic resonance imaging contrast agent",

abstract = "Surface-coating polymers contribute to nanoparticle-based magnetic resonance imaging (MRI) contrast agents because they can affect the relaxometric properties of the nanoparticles. In this study, polyaspartic acid (PASA)-coated ultrasmall Gd2 O3 nanoparticles with an average particle diameter of 2.0 nm were synthesized using the one-pot polyol method. The synthesized nanoparticles exhibited r1 and r2 of 19.1 and = 53.7 s−1 mM−1, respectively, (r1 and r2 are longitudinal and transverse water–proton spin relaxivities, respectively) at 3.0 T MR field, approximately 5 and 10 times higher than those of commercial Gd-chelate contrast agents, respectively. The T1 and T2 MR images could be obtained due to an appreciable r2 /r1 ratio of 2.80, indicating their potential as a dual-modal T1 and T2 MRI contrast agent.",

keywords = "Gadolinium oxide nanoparticle, Magnetic resonance imaging, Polyaspartic acid, T and T dual-modal imaging",

author = "Shanti Marasini and Huan Yue and Adibehalsadat Ghazanfari and Ho, {Son Long} and Park, {Ji Ae} and Soyeon Kim and Hyunsil Cha and Shuwen Liu and Tirusew Tegafaw and Ahmad, {Mohammad Yaseen} and {Al Saidi}, {Abdullah Khamis Ali} and Dejun Zhao and Ying Liu and Chae, {Kwon Seok} and Yongmin Chang and Lee, {Gang Ho}",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = sep,

doi = "10.3390/app11178222",

language = "English",

volume = "11",

journal = "Applied Sciences (Switzerland)",

issn = "2076-3417",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "17",

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Marasini, S, Yue, H, Ghazanfari, A, Ho, SL, Park, JA, Kim, S, Cha, H, Liu, S, Tegafaw, T, Ahmad, MY, Al Saidi, AKA, Zhao, D, Liu, Y, Chae, KS , Chang, Y & Lee, GH 2021, 'Polyaspartic acid-coated paramagnetic gadolinium oxide nanoparticles as a dual-modal t₁ and t₂ magnetic resonance imaging contrast agent', Applied Sciences (Switzerland), vol. 11, no. 17, 8222. https://doi.org/10.3390/app11178222

TY - JOUR

T1 - Polyaspartic acid-coated paramagnetic gadolinium oxide nanoparticles as a dual-modal t1 and t2 magnetic resonance imaging contrast agent

AU - Marasini, Shanti

AU - Yue, Huan

AU - Ghazanfari, Adibehalsadat

AU - Ho, Son Long

AU - Park, Ji Ae

AU - Kim, Soyeon

AU - Cha, Hyunsil

AU - Liu, Shuwen

AU - Tegafaw, Tirusew

AU - Ahmad, Mohammad Yaseen

AU - Al Saidi, Abdullah Khamis Ali

AU - Zhao, Dejun

AU - Liu, Ying

AU - Chae, Kwon Seok

AU - Chang, Yongmin

AU - Lee, Gang Ho

PY - 2021/9

Y1 - 2021/9

N2 - Surface-coating polymers contribute to nanoparticle-based magnetic resonance imaging (MRI) contrast agents because they can affect the relaxometric properties of the nanoparticles. In this study, polyaspartic acid (PASA)-coated ultrasmall Gd2 O3 nanoparticles with an average particle diameter of 2.0 nm were synthesized using the one-pot polyol method. The synthesized nanoparticles exhibited r1 and r2 of 19.1 and = 53.7 s−1 mM−1, respectively, (r1 and r2 are longitudinal and transverse water–proton spin relaxivities, respectively) at 3.0 T MR field, approximately 5 and 10 times higher than those of commercial Gd-chelate contrast agents, respectively. The T1 and T2 MR images could be obtained due to an appreciable r2 /r1 ratio of 2.80, indicating their potential as a dual-modal T1 and T2 MRI contrast agent.

AB - Surface-coating polymers contribute to nanoparticle-based magnetic resonance imaging (MRI) contrast agents because they can affect the relaxometric properties of the nanoparticles. In this study, polyaspartic acid (PASA)-coated ultrasmall Gd2 O3 nanoparticles with an average particle diameter of 2.0 nm were synthesized using the one-pot polyol method. The synthesized nanoparticles exhibited r1 and r2 of 19.1 and = 53.7 s−1 mM−1, respectively, (r1 and r2 are longitudinal and transverse water–proton spin relaxivities, respectively) at 3.0 T MR field, approximately 5 and 10 times higher than those of commercial Gd-chelate contrast agents, respectively. The T1 and T2 MR images could be obtained due to an appreciable r2 /r1 ratio of 2.80, indicating their potential as a dual-modal T1 and T2 MRI contrast agent.

KW - Gadolinium oxide nanoparticle

KW - Magnetic resonance imaging

KW - Polyaspartic acid

KW - T and T dual-modal imaging

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U2 - 10.3390/app11178222

DO - 10.3390/app11178222

M3 - Article

AN - SCOPUS:85114490529

SN - 2076-3417

VL - 11

JO - Applied Sciences (Switzerland)

JF - Applied Sciences (Switzerland)

IS - 17

M1 - 8222

ER -

Polyaspartic acid-coated paramagnetic gadolinium oxide nanoparticles as a dual-modal t₁ and t₂ magnetic resonance imaging contrast agent

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