Polyaspartic acid-coated paramagnetic gadolinium oxide nanoparticles as a dual-modal t1 and t2 magnetic resonance imaging contrast agent

Shanti Marasini; Huan Yue; Adibehalsadat Ghazanfari; Son Long Ho; Ji Ae Park; Soyeon Kim; Hyunsil Cha; Shuwen Liu; Tirusew Tegafaw; Mohammad Yaseen Ahmad; Abdullah Khamis Ali Al Saidi; Dejun Zhao; Ying Liu; Kwon Seok Chae; Yongmin Chang; Gang Ho Lee

doi:10.3390/app11178222

Polyaspartic acid-coated paramagnetic gadolinium oxide nanoparticles as a dual-modal t₁ and t₂ magnetic resonance imaging contrast agent

Shanti Marasini
, Huan Yue
, Adibehalsadat Ghazanfari
, Son Long Ho
, Ji Ae Park
, Soyeon Kim
, Hyunsil Cha
, Shuwen Liu
, Tirusew Tegafaw
, Mohammad Yaseen Ahmad
, Abdullah Khamis Ali Al Saidi
, Dejun Zhao
, Ying Liu
, Kwon Seok Chae
, Yongmin Chang
, Gang Ho Lee

Kyungpook National University
Korea Institute of Radiological and Medical Sciences

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Surface-coating polymers contribute to nanoparticle-based magnetic resonance imaging (MRI) contrast agents because they can affect the relaxometric properties of the nanoparticles. In this study, polyaspartic acid (PASA)-coated ultrasmall Gd₂ O₃ nanoparticles with an average particle diameter of 2.0 nm were synthesized using the one-pot polyol method. The synthesized nanoparticles exhibited r₁ and r₂ of 19.1 and = 53.7 s⁻¹ mM⁻¹, respectively, (r₁ and r₂ are longitudinal and transverse water–proton spin relaxivities, respectively) at 3.0 T MR field, approximately 5 and 10 times higher than those of commercial Gd-chelate contrast agents, respectively. The T₁ and T₂ MR images could be obtained due to an appreciable r₂ /r₁ ratio of 2.80, indicating their potential as a dual-modal T₁ and T₂ MRI contrast agent.

Original language	English
Article number	8222
Journal	Applied Sciences (Switzerland)
Volume	11
Issue number	17
DOIs	https://doi.org/10.3390/app11178222
State	Published - Sep 2021

Keywords

Gadolinium oxide nanoparticle
Magnetic resonance imaging
Polyaspartic acid
T and T dual-modal imaging

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10.3390/app11178222

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Marasini, S., Yue, H., Ghazanfari, A., Ho, S. L., Park, J. A., Kim, S., Cha, H., Liu, S., Tegafaw, T., Ahmad, M. Y., Al Saidi, A. K. A., Zhao, D., Liu, Y., Chae, K. S., Chang, Y., & Lee, G. H. (2021). Polyaspartic acid-coated paramagnetic gadolinium oxide nanoparticles as a dual-modal t₁ and t₂ magnetic resonance imaging contrast agent. Applied Sciences (Switzerland), 11(17), Article 8222. https://doi.org/10.3390/app11178222

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title = "Polyaspartic acid-coated paramagnetic gadolinium oxide nanoparticles as a dual-modal t1 and t2 magnetic resonance imaging contrast agent",

abstract = "Surface-coating polymers contribute to nanoparticle-based magnetic resonance imaging (MRI) contrast agents because they can affect the relaxometric properties of the nanoparticles. In this study, polyaspartic acid (PASA)-coated ultrasmall Gd2 O3 nanoparticles with an average particle diameter of 2.0 nm were synthesized using the one-pot polyol method. The synthesized nanoparticles exhibited r1 and r2 of 19.1 and = 53.7 s−1 mM−1, respectively, (r1 and r2 are longitudinal and transverse water–proton spin relaxivities, respectively) at 3.0 T MR field, approximately 5 and 10 times higher than those of commercial Gd-chelate contrast agents, respectively. The T1 and T2 MR images could be obtained due to an appreciable r2 /r1 ratio of 2.80, indicating their potential as a dual-modal T1 and T2 MRI contrast agent.",

keywords = "Gadolinium oxide nanoparticle, Magnetic resonance imaging, Polyaspartic acid, T and T dual-modal imaging",

author = "Shanti Marasini and Huan Yue and Adibehalsadat Ghazanfari and Ho, \{Son Long\} and Park, \{Ji Ae\} and Soyeon Kim and Hyunsil Cha and Shuwen Liu and Tirusew Tegafaw and Ahmad, \{Mohammad Yaseen\} and \{Al Saidi\}, \{Abdullah Khamis Ali\} and Dejun Zhao and Ying Liu and Chae, \{Kwon Seok\} and Yongmin Chang and Lee, \{Gang Ho\}",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = sep,

doi = "10.3390/app11178222",

language = "English",

volume = "11",

journal = "Applied Sciences (Switzerland)",

issn = "2076-3417",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "17",

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Marasini, S, Yue, H, Ghazanfari, A, Ho, SL, Park, JA, Kim, S, Cha, H, Liu, S, Tegafaw, T, Ahmad, MY, Al Saidi, AKA, Zhao, D, Liu, Y, Chae, KS , Chang, Y & Lee, GH 2021, 'Polyaspartic acid-coated paramagnetic gadolinium oxide nanoparticles as a dual-modal t₁ and t₂ magnetic resonance imaging contrast agent', Applied Sciences (Switzerland), vol. 11, no. 17, 8222. https://doi.org/10.3390/app11178222

TY - JOUR

T1 - Polyaspartic acid-coated paramagnetic gadolinium oxide nanoparticles as a dual-modal t1 and t2 magnetic resonance imaging contrast agent

AU - Marasini, Shanti

AU - Yue, Huan

AU - Ghazanfari, Adibehalsadat

AU - Ho, Son Long

AU - Park, Ji Ae

AU - Kim, Soyeon

AU - Cha, Hyunsil

AU - Liu, Shuwen

AU - Tegafaw, Tirusew

AU - Ahmad, Mohammad Yaseen

AU - Al Saidi, Abdullah Khamis Ali

AU - Zhao, Dejun

AU - Liu, Ying

AU - Chae, Kwon Seok

AU - Chang, Yongmin

AU - Lee, Gang Ho

PY - 2021/9

Y1 - 2021/9

N2 - Surface-coating polymers contribute to nanoparticle-based magnetic resonance imaging (MRI) contrast agents because they can affect the relaxometric properties of the nanoparticles. In this study, polyaspartic acid (PASA)-coated ultrasmall Gd2 O3 nanoparticles with an average particle diameter of 2.0 nm were synthesized using the one-pot polyol method. The synthesized nanoparticles exhibited r1 and r2 of 19.1 and = 53.7 s−1 mM−1, respectively, (r1 and r2 are longitudinal and transverse water–proton spin relaxivities, respectively) at 3.0 T MR field, approximately 5 and 10 times higher than those of commercial Gd-chelate contrast agents, respectively. The T1 and T2 MR images could be obtained due to an appreciable r2 /r1 ratio of 2.80, indicating their potential as a dual-modal T1 and T2 MRI contrast agent.

AB - Surface-coating polymers contribute to nanoparticle-based magnetic resonance imaging (MRI) contrast agents because they can affect the relaxometric properties of the nanoparticles. In this study, polyaspartic acid (PASA)-coated ultrasmall Gd2 O3 nanoparticles with an average particle diameter of 2.0 nm were synthesized using the one-pot polyol method. The synthesized nanoparticles exhibited r1 and r2 of 19.1 and = 53.7 s−1 mM−1, respectively, (r1 and r2 are longitudinal and transverse water–proton spin relaxivities, respectively) at 3.0 T MR field, approximately 5 and 10 times higher than those of commercial Gd-chelate contrast agents, respectively. The T1 and T2 MR images could be obtained due to an appreciable r2 /r1 ratio of 2.80, indicating their potential as a dual-modal T1 and T2 MRI contrast agent.

KW - Gadolinium oxide nanoparticle

KW - Magnetic resonance imaging

KW - Polyaspartic acid

KW - T and T dual-modal imaging

UR - https://www.scopus.com/pages/publications/85114490529

U2 - 10.3390/app11178222

DO - 10.3390/app11178222

M3 - Article

AN - SCOPUS:85114490529

SN - 2076-3417

VL - 11

JO - Applied Sciences (Switzerland)

JF - Applied Sciences (Switzerland)

IS - 17

M1 - 8222

ER -

Polyaspartic acid-coated paramagnetic gadolinium oxide nanoparticles as a dual-modal t₁ and t₂ magnetic resonance imaging contrast agent

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Keywords

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