Polymeric vehicles for topical delivery and related analytical methods

Heui Kyoung Cho, Jin Hun Cho, Seong Hoon Jeong, Dong Chul Cho, Jeong Hyun Yeum, In Woo Cheong

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations

Abstract

Recently a variety of polymeric vehicles, such as micelles, nanoparticles, and polymersomes, have been explored and some of them are clinically used to deliver therapeutic drugs through skin. In topical delivery, the polymeric vehicles as drug carrier should guarantee non-toxicity, long-term stability, and permeation efficacy for drugs, etc. For the development of the successful topical delivery system, it is of importance to develop the polymeric vehicles of well-defined intrinsic properties, such as molecular weights, HLB, chemical composition, topology, specific ligand conjugation and to investigate the effects of the properties on drug permeation behavior. In addition, the role of polymeric vehicles must be elucidated in in vitro and in vivo analyses. This article describes some important features of polymeric vehicles and corresponding analytical methods in topical delivery even though the application span of polymers has been truly broad in the pharmaceutical fields.

Original languageEnglish
Pages (from-to)423-434
Number of pages12
JournalArchives of Pharmacal Research
Volume37
Issue number4
DOIs
StatePublished - Apr 2014

Keywords

  • Block copolymers
  • Polymeric vehicles
  • Skin permeation
  • Topical delivery

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