Polymorphisms in the FAS and FASL genes and risk of lung cancer in a Korean population

Sun Ha Park; Jin Eun Choi; Eun Jin Kim; Jin Sung Jang; Won Kee Lee; Sung Ick Cha; Chang Ho Kim; Sin Kam; Dong Sun Kim; Rang Woon Park; Young Chul Kim; Sung Beom Han; Tae Hoon Jung; Jae Yong Park

doi:10.1016/j.lungcan.2006.09.002

Polymorphisms in the FAS and FASL genes and risk of lung cancer in a Korean population

Sun Ha Park, Jin Eun Choi, Eun Jin Kim, Jin Sung Jang, Won Kee Lee, Sung Ick Cha, Chang Ho Kim, Sin Kam, Dong Sun Kim, Rang Woon Park, Young Chul Kim, Sung Beom Han, Tae Hoon Jung, Jae Yong Park

Department of Medicine

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Background: The FAS and FASL system play an important role in regulating extrinsic apoptotic pathway and inappropriate regulation of this signaling pathway contributes to lung tumorigenesis. Polymorphisms in the promoter region of the FAS (-1377G>A and -670A>G) and FASL (-844C>T) have been shown to alter the transcriptional activities of these genes. In order to evaluate the contribution of these polymorphisms to the risk of lung cancer, we carried out a case-control study in a Korean population. Methods: The FAS and FASL genotypes were determined in 582 lung cancer patients and 582 healthy control subjects who were frequency-matched for age and gender. Results: The FAS and FASL genotypes and the FAS haplotypes exhibited no apparent relationship with the risk of lung cancer. In addition, there was no significant interaction between the FAS and FASL polymorphisms in the development of lung cancer. Conclusion: These results suggest that the FAS-1377G>A and -670A>G and FASL-844C>T polymorphisms do not significantly affect the susceptibility to lung cancer in Koreans.

Original language	English
Pages (from-to)	303-308
Number of pages	6
Journal	Lung Cancer
Volume	54
Issue number	3
DOIs	https://doi.org/10.1016/j.lungcan.2006.09.002
State	Published - Dec 2006

Keywords

FAS
FASL
Lung cancer susceptibility
Polymorphism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.lungcan.2006.09.002

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@article{5a9a7499d09e4956ba46befbb75201eb,

title = "Polymorphisms in the FAS and FASL genes and risk of lung cancer in a Korean population",

abstract = "Background: The FAS and FASL system play an important role in regulating extrinsic apoptotic pathway and inappropriate regulation of this signaling pathway contributes to lung tumorigenesis. Polymorphisms in the promoter region of the FAS (-1377G>A and -670A>G) and FASL (-844C>T) have been shown to alter the transcriptional activities of these genes. In order to evaluate the contribution of these polymorphisms to the risk of lung cancer, we carried out a case-control study in a Korean population. Methods: The FAS and FASL genotypes were determined in 582 lung cancer patients and 582 healthy control subjects who were frequency-matched for age and gender. Results: The FAS and FASL genotypes and the FAS haplotypes exhibited no apparent relationship with the risk of lung cancer. In addition, there was no significant interaction between the FAS and FASL polymorphisms in the development of lung cancer. Conclusion: These results suggest that the FAS-1377G>A and -670A>G and FASL-844C>T polymorphisms do not significantly affect the susceptibility to lung cancer in Koreans.",

keywords = "FAS, FASL, Lung cancer susceptibility, Polymorphism",

author = "Park, {Sun Ha} and Choi, {Jin Eun} and Kim, {Eun Jin} and Jang, {Jin Sung} and Lee, {Won Kee} and Cha, {Sung Ick} and Kim, {Chang Ho} and Sin Kam and Kim, {Dong Sun} and Park, {Rang Woon} and Kim, {Young Chul} and Han, {Sung Beom} and Jung, {Tae Hoon} and Park, {Jae Yong}",

year = "2006",

month = dec,

doi = "10.1016/j.lungcan.2006.09.002",

language = "English",

volume = "54",

pages = "303--308",

journal = "Lung Cancer",

issn = "0169-5002",

publisher = "Elsevier Ireland Ltd",

number = "3",

}

TY - JOUR

T1 - Polymorphisms in the FAS and FASL genes and risk of lung cancer in a Korean population

AU - Park, Sun Ha

AU - Choi, Jin Eun

AU - Kim, Eun Jin

AU - Jang, Jin Sung

AU - Lee, Won Kee

AU - Cha, Sung Ick

AU - Kim, Chang Ho

AU - Kam, Sin

AU - Kim, Dong Sun

AU - Park, Rang Woon

AU - Kim, Young Chul

AU - Han, Sung Beom

AU - Jung, Tae Hoon

AU - Park, Jae Yong

PY - 2006/12

Y1 - 2006/12

N2 - Background: The FAS and FASL system play an important role in regulating extrinsic apoptotic pathway and inappropriate regulation of this signaling pathway contributes to lung tumorigenesis. Polymorphisms in the promoter region of the FAS (-1377G>A and -670A>G) and FASL (-844C>T) have been shown to alter the transcriptional activities of these genes. In order to evaluate the contribution of these polymorphisms to the risk of lung cancer, we carried out a case-control study in a Korean population. Methods: The FAS and FASL genotypes were determined in 582 lung cancer patients and 582 healthy control subjects who were frequency-matched for age and gender. Results: The FAS and FASL genotypes and the FAS haplotypes exhibited no apparent relationship with the risk of lung cancer. In addition, there was no significant interaction between the FAS and FASL polymorphisms in the development of lung cancer. Conclusion: These results suggest that the FAS-1377G>A and -670A>G and FASL-844C>T polymorphisms do not significantly affect the susceptibility to lung cancer in Koreans.

AB - Background: The FAS and FASL system play an important role in regulating extrinsic apoptotic pathway and inappropriate regulation of this signaling pathway contributes to lung tumorigenesis. Polymorphisms in the promoter region of the FAS (-1377G>A and -670A>G) and FASL (-844C>T) have been shown to alter the transcriptional activities of these genes. In order to evaluate the contribution of these polymorphisms to the risk of lung cancer, we carried out a case-control study in a Korean population. Methods: The FAS and FASL genotypes were determined in 582 lung cancer patients and 582 healthy control subjects who were frequency-matched for age and gender. Results: The FAS and FASL genotypes and the FAS haplotypes exhibited no apparent relationship with the risk of lung cancer. In addition, there was no significant interaction between the FAS and FASL polymorphisms in the development of lung cancer. Conclusion: These results suggest that the FAS-1377G>A and -670A>G and FASL-844C>T polymorphisms do not significantly affect the susceptibility to lung cancer in Koreans.

KW - FAS

KW - FASL

KW - Lung cancer susceptibility

KW - Polymorphism

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U2 - 10.1016/j.lungcan.2006.09.002

DO - 10.1016/j.lungcan.2006.09.002

M3 - Article

C2 - 17014925

AN - SCOPUS:33750309227

SN - 0169-5002

VL - 54

SP - 303

EP - 308

JO - Lung Cancer

JF - Lung Cancer

IS - 3

ER -

Polymorphisms in the FAS and FASL genes and risk of lung cancer in a Korean population

Abstract

Keywords

UN SDGs

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