TY - JOUR
T1 - Poly(N-vinyl caprolactam) grown on nanographene oxide as an effective nanocargo for drug delivery
AU - Kavitha, Thangavelu
AU - Kang, Inn Kyu
AU - Park, Soo Young
PY - 2014/3/1
Y1 - 2014/3/1
N2 - This study evaluated graphene oxide functionalized covalently with poly N-vinyl caprolactam (GO-PVCL) via in situ atomic transfer radical polymerization (ATRP), as a nano-cargo carrier for the efficient delivery of drugs into cells. Water-soluble GO-PVCL exhibited excellent stability in physiological solutions. An anti-cancer drug, camptothecin (CPT), was then loaded onto GO-PVCL with a high payload (20%) through π π stacking and hydrophobic interactions, and its release could be controlled by varying the pH. PVCL grafted onto GO offers an additional advantage of targeted delivery according to temperature. GO-PVCL showed no obvious toxicity, whereas the CPT-loaded GO-PVCL showed high potency in killing cancer cells in vitro. The drug transportation mechanism was found to be energy-dependent endocytosis. Overall, this study revealed GO-PVCL to be a promising drug delivery vector with high biocompatibility, solubility and stability in physiological solutions, and good payload capacity owing to its small size, low cost, large specific area, ready scalability, and useful non-covalent interactions. This material is expected to be a novel material propitious for biomedical applications.
AB - This study evaluated graphene oxide functionalized covalently with poly N-vinyl caprolactam (GO-PVCL) via in situ atomic transfer radical polymerization (ATRP), as a nano-cargo carrier for the efficient delivery of drugs into cells. Water-soluble GO-PVCL exhibited excellent stability in physiological solutions. An anti-cancer drug, camptothecin (CPT), was then loaded onto GO-PVCL with a high payload (20%) through π π stacking and hydrophobic interactions, and its release could be controlled by varying the pH. PVCL grafted onto GO offers an additional advantage of targeted delivery according to temperature. GO-PVCL showed no obvious toxicity, whereas the CPT-loaded GO-PVCL showed high potency in killing cancer cells in vitro. The drug transportation mechanism was found to be energy-dependent endocytosis. Overall, this study revealed GO-PVCL to be a promising drug delivery vector with high biocompatibility, solubility and stability in physiological solutions, and good payload capacity owing to its small size, low cost, large specific area, ready scalability, and useful non-covalent interactions. This material is expected to be a novel material propitious for biomedical applications.
KW - Biocompatible
KW - Graphene oxide
KW - Molecular weight dependent LCST
KW - Nanocargo
KW - Poly(N-vinyl caprolactam)
UR - http://www.scopus.com/inward/record.url?scp=84889683082&partnerID=8YFLogxK
U2 - 10.1016/j.colsurfb.2013.11.022
DO - 10.1016/j.colsurfb.2013.11.022
M3 - Article
C2 - 24316754
AN - SCOPUS:84889683082
SN - 0927-7765
VL - 115
SP - 37
EP - 45
JO - Colloids and Surfaces B: Biointerfaces
JF - Colloids and Surfaces B: Biointerfaces
ER -
