Polysaccharides isolated from Phellinus baumii stimulate murine splenocyte proliferation and inhibit the lipopolysaccharide-induced nitric oxide production in RAW264.7 murine macrophages

Z. Q. Chang; B. C. Oh; M. H. Rhee; J. C. Kim; S. P. Lee; S. C. Park

doi:10.1007/s11274-006-9277-3

Polysaccharides isolated from Phellinus baumii stimulate murine splenocyte proliferation and inhibit the lipopolysaccharide-induced nitric oxide production in RAW264.7 murine macrophages

Z. Q. Chang, B. C. Oh, M. H. Rhee, J. C. Kim, S. P. Lee, S. C. Park

Department of Veterinary Medicine

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Polysaccharides isolated from Phellinus baumii (PBP) significantly enhanced both lipopolysaccharide (LPS)-induced B lymphocyte proliferation and concanavalin A (Con A)-induced T lymphocyte proliferation. However, PBP (12.5-100 μg ml^-1) significantly suppressed the LPS-induced nitric oxide (NO) production in RAW264.7 cells in a concentration-dependent manner. The maximal inhibition of PBP on NO production was 37.5% at 100 μg ml ^-1. These results provide useful in vitro information to explain the immunostimulating activity and anti-inflammatory activity of PBP.

Original language	English
Pages (from-to)	723-727
Number of pages	5
Journal	World Journal of Microbiology and Biotechnology
Volume	23
Issue number	5
DOIs	https://doi.org/10.1007/s11274-006-9277-3
State	Published - May 2007

Keywords

Nitric oxide
Phellinus baumii
Polysaccharide
Splenocyte proliferation

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10.1007/s11274-006-9277-3

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Chang, Z. Q., Oh, B. C., Rhee, M. H., Kim, J. C., Lee, S. P., & Park, S. C. (2007). Polysaccharides isolated from Phellinus baumii stimulate murine splenocyte proliferation and inhibit the lipopolysaccharide-induced nitric oxide production in RAW264.7 murine macrophages. World Journal of Microbiology and Biotechnology, 23(5), 723-727. https://doi.org/10.1007/s11274-006-9277-3

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title = "Polysaccharides isolated from Phellinus baumii stimulate murine splenocyte proliferation and inhibit the lipopolysaccharide-induced nitric oxide production in RAW264.7 murine macrophages",

abstract = "Polysaccharides isolated from Phellinus baumii (PBP) significantly enhanced both lipopolysaccharide (LPS)-induced B lymphocyte proliferation and concanavalin A (Con A)-induced T lymphocyte proliferation. However, PBP (12.5-100 μg ml-1) significantly suppressed the LPS-induced nitric oxide (NO) production in RAW264.7 cells in a concentration-dependent manner. The maximal inhibition of PBP on NO production was 37.5% at 100 μg ml -1. These results provide useful in vitro information to explain the immunostimulating activity and anti-inflammatory activity of PBP.",

keywords = "Nitric oxide, Phellinus baumii, Polysaccharide, Splenocyte proliferation",

author = "Chang, {Z. Q.} and Oh, {B. C.} and Rhee, {M. H.} and Kim, {J. C.} and Lee, {S. P.} and Park, {S. C.}",

year = "2007",

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Chang, ZQ, Oh, BC, Rhee, MH, Kim, JC, Lee, SP & Park, SC 2007, 'Polysaccharides isolated from Phellinus baumii stimulate murine splenocyte proliferation and inhibit the lipopolysaccharide-induced nitric oxide production in RAW264.7 murine macrophages', World Journal of Microbiology and Biotechnology, vol. 23, no. 5, pp. 723-727. https://doi.org/10.1007/s11274-006-9277-3

Polysaccharides isolated from Phellinus baumii stimulate murine splenocyte proliferation and inhibit the lipopolysaccharide-induced nitric oxide production in RAW264.7 murine macrophages. / Chang, Z. Q.; Oh, B. C.; Rhee, M. H. et al.
In: World Journal of Microbiology and Biotechnology, Vol. 23, No. 5, 05.2007, p. 723-727.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Polysaccharides isolated from Phellinus baumii stimulate murine splenocyte proliferation and inhibit the lipopolysaccharide-induced nitric oxide production in RAW264.7 murine macrophages

AU - Chang, Z. Q.

AU - Oh, B. C.

AU - Rhee, M. H.

AU - Kim, J. C.

AU - Lee, S. P.

AU - Park, S. C.

PY - 2007/5

Y1 - 2007/5

N2 - Polysaccharides isolated from Phellinus baumii (PBP) significantly enhanced both lipopolysaccharide (LPS)-induced B lymphocyte proliferation and concanavalin A (Con A)-induced T lymphocyte proliferation. However, PBP (12.5-100 μg ml-1) significantly suppressed the LPS-induced nitric oxide (NO) production in RAW264.7 cells in a concentration-dependent manner. The maximal inhibition of PBP on NO production was 37.5% at 100 μg ml -1. These results provide useful in vitro information to explain the immunostimulating activity and anti-inflammatory activity of PBP.

AB - Polysaccharides isolated from Phellinus baumii (PBP) significantly enhanced both lipopolysaccharide (LPS)-induced B lymphocyte proliferation and concanavalin A (Con A)-induced T lymphocyte proliferation. However, PBP (12.5-100 μg ml-1) significantly suppressed the LPS-induced nitric oxide (NO) production in RAW264.7 cells in a concentration-dependent manner. The maximal inhibition of PBP on NO production was 37.5% at 100 μg ml -1. These results provide useful in vitro information to explain the immunostimulating activity and anti-inflammatory activity of PBP.

KW - Nitric oxide

KW - Phellinus baumii

KW - Polysaccharide

KW - Splenocyte proliferation

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M3 - Article

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SN - 0959-3993

VL - 23

SP - 723

EP - 727

JO - World Journal of Microbiology and Biotechnology

JF - World Journal of Microbiology and Biotechnology

IS - 5

ER -

Polysaccharides isolated from Phellinus baumii stimulate murine splenocyte proliferation and inhibit the lipopolysaccharide-induced nitric oxide production in RAW264.7 murine macrophages

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