Polysaccharides isolated from Phellinus baumii stimulate murine splenocyte proliferation and inhibit the lipopolysaccharide-induced nitric oxide production in RAW264.7 murine macrophages

Z. Q. Chang; B. C. Oh; M. H. Rhee; J. C. Kim; S. P. Lee; S. C. Park

doi:10.1007/s11274-006-9277-3

Polysaccharides isolated from Phellinus baumii stimulate murine splenocyte proliferation and inhibit the lipopolysaccharide-induced nitric oxide production in RAW264.7 murine macrophages

Z. Q. Chang
, B. C. Oh
, M. H. Rhee
, J. C. Kim
, S. P. Lee
, S. C. Park

Department of Veterinary Medicine

Kyungpook National University
Korea Research Institute of Bioscience and Biotechnology
Chonnam National University
Keimyung University

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Polysaccharides isolated from Phellinus baumii (PBP) significantly enhanced both lipopolysaccharide (LPS)-induced B lymphocyte proliferation and concanavalin A (Con A)-induced T lymphocyte proliferation. However, PBP (12.5-100 μg ml^-1) significantly suppressed the LPS-induced nitric oxide (NO) production in RAW264.7 cells in a concentration-dependent manner. The maximal inhibition of PBP on NO production was 37.5% at 100 μg ml ^-1. These results provide useful in vitro information to explain the immunostimulating activity and anti-inflammatory activity of PBP.

Original language	English
Pages (from-to)	723-727
Number of pages	5
Journal	World Journal of Microbiology and Biotechnology
Volume	23
Issue number	5
DOIs	https://doi.org/10.1007/s11274-006-9277-3
State	Published - May 2007

Keywords

Nitric oxide
Phellinus baumii
Polysaccharide
Splenocyte proliferation

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10.1007/s11274-006-9277-3

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Chang, Z. Q., Oh, B. C., Rhee, M. H., Kim, J. C., Lee, S. P., & Park, S. C. (2007). Polysaccharides isolated from Phellinus baumii stimulate murine splenocyte proliferation and inhibit the lipopolysaccharide-induced nitric oxide production in RAW264.7 murine macrophages. World Journal of Microbiology and Biotechnology, 23(5), 723-727. https://doi.org/10.1007/s11274-006-9277-3

@article{f26ad1aa4c774131ad374af76addb45f,

title = "Polysaccharides isolated from Phellinus baumii stimulate murine splenocyte proliferation and inhibit the lipopolysaccharide-induced nitric oxide production in RAW264.7 murine macrophages",

abstract = "Polysaccharides isolated from Phellinus baumii (PBP) significantly enhanced both lipopolysaccharide (LPS)-induced B lymphocyte proliferation and concanavalin A (Con A)-induced T lymphocyte proliferation. However, PBP (12.5-100 μg ml-1) significantly suppressed the LPS-induced nitric oxide (NO) production in RAW264.7 cells in a concentration-dependent manner. The maximal inhibition of PBP on NO production was 37.5\% at 100 μg ml -1. These results provide useful in vitro information to explain the immunostimulating activity and anti-inflammatory activity of PBP.",

keywords = "Nitric oxide, Phellinus baumii, Polysaccharide, Splenocyte proliferation",

author = "Chang, \{Z. Q.\} and Oh, \{B. C.\} and Rhee, \{M. H.\} and Kim, \{J. C.\} and Lee, \{S. P.\} and Park, \{S. C.\}",

year = "2007",

month = may,

doi = "10.1007/s11274-006-9277-3",

language = "English",

volume = "23",

pages = "723--727",

journal = "World Journal of Microbiology and Biotechnology",

issn = "0959-3993",

publisher = "Springer Science and Business Media B.V.",

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}

Chang, ZQ, Oh, BC, Rhee, MH, Kim, JC, Lee, SP & Park, SC 2007, 'Polysaccharides isolated from Phellinus baumii stimulate murine splenocyte proliferation and inhibit the lipopolysaccharide-induced nitric oxide production in RAW264.7 murine macrophages', World Journal of Microbiology and Biotechnology, vol. 23, no. 5, pp. 723-727. https://doi.org/10.1007/s11274-006-9277-3

Polysaccharides isolated from Phellinus baumii stimulate murine splenocyte proliferation and inhibit the lipopolysaccharide-induced nitric oxide production in RAW264.7 murine macrophages. / Chang, Z. Q.; Oh, B. C.; Rhee, M. H. et al.
In: World Journal of Microbiology and Biotechnology, Vol. 23, No. 5, 05.2007, p. 723-727.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Polysaccharides isolated from Phellinus baumii stimulate murine splenocyte proliferation and inhibit the lipopolysaccharide-induced nitric oxide production in RAW264.7 murine macrophages

AU - Chang, Z. Q.

AU - Oh, B. C.

AU - Rhee, M. H.

AU - Kim, J. C.

AU - Lee, S. P.

AU - Park, S. C.

PY - 2007/5

Y1 - 2007/5

N2 - Polysaccharides isolated from Phellinus baumii (PBP) significantly enhanced both lipopolysaccharide (LPS)-induced B lymphocyte proliferation and concanavalin A (Con A)-induced T lymphocyte proliferation. However, PBP (12.5-100 μg ml-1) significantly suppressed the LPS-induced nitric oxide (NO) production in RAW264.7 cells in a concentration-dependent manner. The maximal inhibition of PBP on NO production was 37.5% at 100 μg ml -1. These results provide useful in vitro information to explain the immunostimulating activity and anti-inflammatory activity of PBP.

AB - Polysaccharides isolated from Phellinus baumii (PBP) significantly enhanced both lipopolysaccharide (LPS)-induced B lymphocyte proliferation and concanavalin A (Con A)-induced T lymphocyte proliferation. However, PBP (12.5-100 μg ml-1) significantly suppressed the LPS-induced nitric oxide (NO) production in RAW264.7 cells in a concentration-dependent manner. The maximal inhibition of PBP on NO production was 37.5% at 100 μg ml -1. These results provide useful in vitro information to explain the immunostimulating activity and anti-inflammatory activity of PBP.

KW - Nitric oxide

KW - Phellinus baumii

KW - Polysaccharide

KW - Splenocyte proliferation

UR - https://www.scopus.com/pages/publications/34248189105

U2 - 10.1007/s11274-006-9277-3

DO - 10.1007/s11274-006-9277-3

M3 - Article

AN - SCOPUS:34248189105

SN - 0959-3993

VL - 23

SP - 723

EP - 727

JO - World Journal of Microbiology and Biotechnology

JF - World Journal of Microbiology and Biotechnology

IS - 5

ER -

Polysaccharides isolated from Phellinus baumii stimulate murine splenocyte proliferation and inhibit the lipopolysaccharide-induced nitric oxide production in RAW264.7 murine macrophages

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Keywords

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