Polysaccharides isolated from Phellinus gilvus inhibit melanoma growth in mice

Jae Sung Bae; Kwang Ho Jang; Hyunee Yim; Hee Kyung Jin

doi:10.1016/j.canlet.2004.08.002

Polysaccharides isolated from Phellinus gilvus inhibit melanoma growth in mice

Jae Sung Bae, Kwang Ho Jang, Hyunee Yim, Hee Kyung Jin

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

There is no information about the effect of polysaccharides from fungus, Phellinus gilvus (PG) on melanoma. The effect of PG on the proliferation and apoptosis of the B16F10 melanoma cell line was determined by a sulforhodamine B (SRB) and a sandwich enzyme-linked immunosorbent assay. The in vivo effect of PG on B16F10 melanoma cells allografted in athymic nude mice was investigated. PG decreased cell proliferation and increased cell apoptosis in a dose dependent manner in vitro. Also, PG significantly inhibits melanoma growth in mice. The PG anti-tumor effect in vivo was associated with a significant increase in the melanoma apoptosis rate. These findings support PG as a therapeutic agent against melanoma.

Original language	English
Pages (from-to)	43-52
Number of pages	10
Journal	Cancer Letters
Volume	218
Issue number	1
DOIs	https://doi.org/10.1016/j.canlet.2004.08.002
State	Published - 31 Jan 2005

Keywords

Apoptosis
Athymic mice
Melanoma
Phellinus gilvus
Polysaccharides

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.canlet.2004.08.002

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title = "Polysaccharides isolated from Phellinus gilvus inhibit melanoma growth in mice",

abstract = "There is no information about the effect of polysaccharides from fungus, Phellinus gilvus (PG) on melanoma. The effect of PG on the proliferation and apoptosis of the B16F10 melanoma cell line was determined by a sulforhodamine B (SRB) and a sandwich enzyme-linked immunosorbent assay. The in vivo effect of PG on B16F10 melanoma cells allografted in athymic nude mice was investigated. PG decreased cell proliferation and increased cell apoptosis in a dose dependent manner in vitro. Also, PG significantly inhibits melanoma growth in mice. The PG anti-tumor effect in vivo was associated with a significant increase in the melanoma apoptosis rate. These findings support PG as a therapeutic agent against melanoma.",

keywords = "Apoptosis, Athymic mice, Melanoma, Phellinus gilvus, Polysaccharides",

author = "Bae, {Jae Sung} and Jang, {Kwang Ho} and Hyunee Yim and Jin, {Hee Kyung}",

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T1 - Polysaccharides isolated from Phellinus gilvus inhibit melanoma growth in mice

AU - Bae, Jae Sung

AU - Jang, Kwang Ho

AU - Yim, Hyunee

AU - Jin, Hee Kyung

PY - 2005/1/31

Y1 - 2005/1/31

N2 - There is no information about the effect of polysaccharides from fungus, Phellinus gilvus (PG) on melanoma. The effect of PG on the proliferation and apoptosis of the B16F10 melanoma cell line was determined by a sulforhodamine B (SRB) and a sandwich enzyme-linked immunosorbent assay. The in vivo effect of PG on B16F10 melanoma cells allografted in athymic nude mice was investigated. PG decreased cell proliferation and increased cell apoptosis in a dose dependent manner in vitro. Also, PG significantly inhibits melanoma growth in mice. The PG anti-tumor effect in vivo was associated with a significant increase in the melanoma apoptosis rate. These findings support PG as a therapeutic agent against melanoma.

AB - There is no information about the effect of polysaccharides from fungus, Phellinus gilvus (PG) on melanoma. The effect of PG on the proliferation and apoptosis of the B16F10 melanoma cell line was determined by a sulforhodamine B (SRB) and a sandwich enzyme-linked immunosorbent assay. The in vivo effect of PG on B16F10 melanoma cells allografted in athymic nude mice was investigated. PG decreased cell proliferation and increased cell apoptosis in a dose dependent manner in vitro. Also, PG significantly inhibits melanoma growth in mice. The PG anti-tumor effect in vivo was associated with a significant increase in the melanoma apoptosis rate. These findings support PG as a therapeutic agent against melanoma.

KW - Apoptosis

KW - Athymic mice

KW - Melanoma

KW - Phellinus gilvus

KW - Polysaccharides

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DO - 10.1016/j.canlet.2004.08.002

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SP - 43

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JO - Cancer Letters

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Polysaccharides isolated from Phellinus gilvus inhibit melanoma growth in mice

Abstract

Keywords

UN SDGs

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