Porphyrin shell microbubbles with intrinsic ultrasound and photoacoustic properties

Elizabeth Huynh; Jonathan F. Lovell; Brandon L. Helfield; Mansik Jeon; Chulhong Kim; David E. Goertz; Brian C. Wilson; Gang Zheng

doi:10.1021/ja305988f

Porphyrin shell microbubbles with intrinsic ultrasound and photoacoustic properties

Elizabeth Huynh, Jonathan F. Lovell, Brandon L. Helfield, Mansik Jeon, Chulhong Kim, David E. Goertz, Brian C. Wilson, Gang Zheng

School of Electronics Engineering

Research output: Contribution to journal › Article › peer-review

187 Scopus citations

Abstract

Porphyrin-phospholipid conjugates were used to create photonic microbubbles (MBs) having a porphyrin shell ("porshe"), and their acoustic and photoacoustic properties were investigated. The inclusion of porphyrin-lipid in the MB shell increased the yield, improved the serum stability, and generated a narrow volumetric size distribution with a peak size of 2.7 ± 0.2 μm. Using an acoustic model, we calculated the porshe stiffness to be 3-5 times greater than that of commercial lipid MBs. Porshe MBs were found to be intrinsically suitable for both ultrasound and photoacoustic imaging with a resonance frequency of 9-10 MHz. The distinctive properties of porshe MBs make them potentially advantageous for a broad range of biomedical imaging and therapeutic applications.

Original language	English
Pages (from-to)	16464-16467
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	134
Issue number	40
DOIs	https://doi.org/10.1021/ja305988f
State	Published - 10 Oct 2012

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title = "Porphyrin shell microbubbles with intrinsic ultrasound and photoacoustic properties",

abstract = "Porphyrin-phospholipid conjugates were used to create photonic microbubbles (MBs) having a porphyrin shell ({"}porshe{"}), and their acoustic and photoacoustic properties were investigated. The inclusion of porphyrin-lipid in the MB shell increased the yield, improved the serum stability, and generated a narrow volumetric size distribution with a peak size of 2.7 ± 0.2 μm. Using an acoustic model, we calculated the porshe stiffness to be 3-5 times greater than that of commercial lipid MBs. Porshe MBs were found to be intrinsically suitable for both ultrasound and photoacoustic imaging with a resonance frequency of 9-10 MHz. The distinctive properties of porshe MBs make them potentially advantageous for a broad range of biomedical imaging and therapeutic applications.",

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T1 - Porphyrin shell microbubbles with intrinsic ultrasound and photoacoustic properties

AU - Huynh, Elizabeth

AU - Lovell, Jonathan F.

AU - Helfield, Brandon L.

AU - Jeon, Mansik

AU - Kim, Chulhong

AU - Goertz, David E.

AU - Wilson, Brian C.

AU - Zheng, Gang

PY - 2012/10/10

Y1 - 2012/10/10

N2 - Porphyrin-phospholipid conjugates were used to create photonic microbubbles (MBs) having a porphyrin shell ("porshe"), and their acoustic and photoacoustic properties were investigated. The inclusion of porphyrin-lipid in the MB shell increased the yield, improved the serum stability, and generated a narrow volumetric size distribution with a peak size of 2.7 ± 0.2 μm. Using an acoustic model, we calculated the porshe stiffness to be 3-5 times greater than that of commercial lipid MBs. Porshe MBs were found to be intrinsically suitable for both ultrasound and photoacoustic imaging with a resonance frequency of 9-10 MHz. The distinctive properties of porshe MBs make them potentially advantageous for a broad range of biomedical imaging and therapeutic applications.

AB - Porphyrin-phospholipid conjugates were used to create photonic microbubbles (MBs) having a porphyrin shell ("porshe"), and their acoustic and photoacoustic properties were investigated. The inclusion of porphyrin-lipid in the MB shell increased the yield, improved the serum stability, and generated a narrow volumetric size distribution with a peak size of 2.7 ± 0.2 μm. Using an acoustic model, we calculated the porshe stiffness to be 3-5 times greater than that of commercial lipid MBs. Porshe MBs were found to be intrinsically suitable for both ultrasound and photoacoustic imaging with a resonance frequency of 9-10 MHz. The distinctive properties of porshe MBs make them potentially advantageous for a broad range of biomedical imaging and therapeutic applications.

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JO - Journal of the American Chemical Society

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ER -

Porphyrin shell microbubbles with intrinsic ultrasound and photoacoustic properties

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