Positron emission tomography imaging of drug-induced tumor apoptosis with a caspase-triggered nanoaggregation probe

Bin Shen, Jongho Jeon, Mikael Palner, Deju Ye, Adam Shuhendler, Frederick T. Chin, Jianghong Rao

Research output: Contribution to journalArticlepeer-review

94 Scopus citations

Abstract

Drug Design: An 18F-labeled caspase-3-sensitive nanoaggregation positron emission tomography tracer was prepared and evaluated for imaging the caspase-3 activity in doxorubicin-treated tumor xenografts. Enhanced retention of the 18F activity in apoptotic tumors is achieved through intramolecular macrocyclization and in situ aggregation upon caspase-3 activation (see picture).

Original languageEnglish
Pages (from-to)10511-10514
Number of pages4
JournalAngewandte Chemie - International Edition
Volume52
Issue number40
DOIs
StatePublished - 27 Sep 2013

Keywords

  • apoptosis
  • caspase-3
  • cyclization
  • drug design
  • positron emission tomography

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