Positron emission tomography imaging of drug-induced tumor apoptosis with a caspase-triggered nanoaggregation probe

Bin Shen; Jongho Jeon; Mikael Palner; Deju Ye; Adam Shuhendler; Frederick T. Chin; Jianghong Rao

doi:10.1002/anie.201303422

Positron emission tomography imaging of drug-induced tumor apoptosis with a caspase-triggered nanoaggregation probe

Bin Shen, Jongho Jeon, Mikael Palner, Deju Ye, Adam Shuhendler, Frederick T. Chin, Jianghong Rao

Department of Applied Chemistry

Stanford University

Research output: Contribution to journal › Article › peer-review

99 Scopus citations

Abstract

Drug Design: An ¹⁸F-labeled caspase-3-sensitive nanoaggregation positron emission tomography tracer was prepared and evaluated for imaging the caspase-3 activity in doxorubicin-treated tumor xenografts. Enhanced retention of the ¹⁸F activity in apoptotic tumors is achieved through intramolecular macrocyclization and in situ aggregation upon caspase-3 activation (see picture).

Original language	English
Pages (from-to)	10511-10514
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	40
DOIs	https://doi.org/10.1002/anie.201303422
State	Published - 27 Sep 2013

Keywords

apoptosis
caspase-3
cyclization
drug design
positron emission tomography

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10.1002/anie.201303422

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AU - Shuhendler, Adam

AU - Chin, Frederick T.

AU - Rao, Jianghong

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KW - caspase-3

KW - cyclization

KW - drug design

KW - positron emission tomography

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Positron emission tomography imaging of drug-induced tumor apoptosis with a caspase-triggered nanoaggregation probe

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Keywords

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