Positron emission tomography imaging of drug-induced tumor apoptosis with a caspase-triggered nanoaggregation probe

Bin Shen; Jongho Jeon; Mikael Palner; Deju Ye; Adam Shuhendler; Frederick T. Chin; Jianghong Rao

doi:10.1002/anie.201303422

Positron emission tomography imaging of drug-induced tumor apoptosis with a caspase-triggered nanoaggregation probe

Bin Shen
, Jongho Jeon
, Mikael Palner
, Deju Ye
, Adam Shuhendler
, Frederick T. Chin
, Jianghong Rao

Department of Applied Chemistry

Stanford University

Research output: Contribution to journal › Article › peer-review

102 Scopus citations

Abstract

Drug Design: An ¹⁸F-labeled caspase-3-sensitive nanoaggregation positron emission tomography tracer was prepared and evaluated for imaging the caspase-3 activity in doxorubicin-treated tumor xenografts. Enhanced retention of the ¹⁸F activity in apoptotic tumors is achieved through intramolecular macrocyclization and in situ aggregation upon caspase-3 activation (see picture).

Original language	English
Pages (from-to)	10511-10514
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	40
DOIs	https://doi.org/10.1002/anie.201303422
State	Published - 27 Sep 2013

Keywords

apoptosis
caspase-3
cyclization
drug design
positron emission tomography

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10.1002/anie.201303422

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abstract = "Drug Design: An 18F-labeled caspase-3-sensitive nanoaggregation positron emission tomography tracer was prepared and evaluated for imaging the caspase-3 activity in doxorubicin-treated tumor xenografts. Enhanced retention of the 18F activity in apoptotic tumors is achieved through intramolecular macrocyclization and in situ aggregation upon caspase-3 activation (see picture).",

keywords = "apoptosis, caspase-3, cyclization, drug design, positron emission tomography",

author = "Bin Shen and Jongho Jeon and Mikael Palner and Deju Ye and Adam Shuhendler and Chin, \{Frederick T.\} and Jianghong Rao",

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AU - Shen, Bin

AU - Jeon, Jongho

AU - Palner, Mikael

AU - Ye, Deju

AU - Shuhendler, Adam

AU - Chin, Frederick T.

AU - Rao, Jianghong

PY - 2013/9/27

Y1 - 2013/9/27

N2 - Drug Design: An 18F-labeled caspase-3-sensitive nanoaggregation positron emission tomography tracer was prepared and evaluated for imaging the caspase-3 activity in doxorubicin-treated tumor xenografts. Enhanced retention of the 18F activity in apoptotic tumors is achieved through intramolecular macrocyclization and in situ aggregation upon caspase-3 activation (see picture).

AB - Drug Design: An 18F-labeled caspase-3-sensitive nanoaggregation positron emission tomography tracer was prepared and evaluated for imaging the caspase-3 activity in doxorubicin-treated tumor xenografts. Enhanced retention of the 18F activity in apoptotic tumors is achieved through intramolecular macrocyclization and in situ aggregation upon caspase-3 activation (see picture).

KW - apoptosis

KW - caspase-3

KW - cyclization

KW - drug design

KW - positron emission tomography

UR - https://www.scopus.com/pages/publications/84884831798

U2 - 10.1002/anie.201303422

DO - 10.1002/anie.201303422

M3 - Article

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AN - SCOPUS:84884831798

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ER -

Positron emission tomography imaging of drug-induced tumor apoptosis with a caspase-triggered nanoaggregation probe

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Keywords

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