Potential Biomarkers for NSAID-Exacerbated Respiratory Disease

Hanki Park, Youngwoo Choi, Chang Gyu Jung, Hae Sim Park

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations

Abstract

Asthma is a common chronic disease with several variant phenotypes and endotypes. NSAID-exacerbated respiratory disease (NERD) is one such endotype characterized by asthma, chronic rhinosinusitis (CRS) with nasal polyps, and hypersensitivity to aspirin/cyclooxygenase-1 inhibitors. NERD is more associated with severe asthma than other asthma phenotypes. Regarding diagnosis, aspirin challenge tests via the oral or bronchial route are a standard diagnostic method; reliable in vitro diagnostic tests are not available. Recent studies have reported various biomarkers of phenotype, diagnosis, and prognosis. In this review, we summarized the known potential biomarkers of NERD that are distinct from those of aspirin-tolerant asthma. We also provided an overview of the different NERD subgroups.

Original languageEnglish
Article number8160148
JournalMediators of Inflammation
Volume2017
DOIs
StatePublished - 2017

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