Predictors of immediate bleeding during endoscopic submucosal dissection in gastric lesions

Seong Woo Jeon, Min Kyu Jung, Chang Min Cho, Won Young Tak, Young Oh Kweon, Sung Kook Kim, Yong Hwan Choi

Research output: Contribution to journalArticlepeer-review

93 Scopus citations

Abstract

Background Although there have been several reports regarding complications, especially immediate bleeding, of endoscopic mucosal resection for a gastric neoplasm, little is known about the predictors of complications of endoscopic submucosal dissection (ESD). Thus, this study was performed to evaluate the predictive factors for immediate bleeding during ESD procedures. Methods We analyzed 167 patients with 167 gastric lesions from June 2006 to June 2007. Patient-related variables (age, gender, history of aspirin or anti-platelet agents, triple therapy for H. pylori, and use of a proton pump inhibitor), endoscopic variables (lesion size, location, type, and mucosal ulceration), procedure-related variables (procedure time and volume of submucosal injection), and the pathology diagnosis were evaluated as potential risk factors. Results The mean age of the patients was 62 years. The mean size of the lesions was 15 mm. The overall en bloc resection rate was 98.2%. Immediate bleeding occurred in 20 out of 167 patients. Delayed bleeding was seen in only three patients within 24 h after the procedure. Older age and the location of the lesions (antrum) were associated with a lower frequency of bleeding (p = 0.006 and p = 0.007, respectively). On multivariate analysis, an older age (OR 0.931, 95% CI 0.88-0.98) and the location of the lesion (antrum; OR 0.254, 95% CI 0.09-0.69) were significant predictive factors for a successful ESD without bleeding. Conclusion The results of this study demonstrated that age and lesion location were related to the ESD procedure outcome.

Original languageEnglish
Pages (from-to)1974-1979
Number of pages6
JournalSurgical Endoscopy and Other Interventional Techniques
Volume23
Issue number9
DOIs
StatePublished - Sep 2009

Keywords

  • Bleeding
  • Endoscopic submucosal dissection
  • Gastric dysplasia

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