Predictors of relapse in patients with organizing pneumonia

Minjung Kim, Seung Ick Cha, Hyewon Seo, Kyung Min Shin, Jae Kwang Lim, Hyera Kim, Seung Soo Yoo, Jaehee Lee, Shin Yup Lee, Chang Ho Kim, Jae Yong Park

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Background: Although organizing pneumonia (OP) responds well to corticosteroid therapy, relapse is common during dose reduction or follow-up. Predictors of relapse in OP patients remain to be established. The aim of the present study was to identify factors related to relapse in OP patients. Methods: This study was retrospectively performed in a tertiary referral center. Of 66 OP patients who were improved with or without treatment, 20 (30%) experienced relapse. The clinical and radiologic parameters in the relapse patient group (n=20) were compared to that in the non-relapse group (n=46). Results: Multivariate analysis demonstrated that percent predicted forced vital capacity (FVC), PaO2/FiO2, and serum protein level were significant predictors of relapse in OP patients (odds ratio [OR], 0.82; 95% confidence interval [CI], 0.70-0.97; p=0.018; OR, 1.02; 95% CI, 1.00-1.04; p=0.042; and OR, 0.06; 95% CI, 0.01-0.87; p=0.039, respectively). Conclusion: This study shows that FVC, PaO2/FiO2 and serum protein level at presentation can significantly predict relapse in OP patients.

Original languageEnglish
Pages (from-to)190-195
Number of pages6
JournalTuberculosis and Respiratory Diseases
Volume78
Issue number3
DOIs
StatePublished - Jul 2015

Keywords

  • Cryptogenic organizing pneumonia
  • Recurrence
  • Vital capacity

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