Preliminary study of neurofilament light chain as a biomarker for hypoxia-induced neuronal injury in dogs

Taesik Yun; Yeon Chae; Yoonhoi Koo; Dohee Lee; Hakhyun Kim; Mhan Pyo Yang; Byeong Teck Kang

doi:10.3389/fvets.2023.1284306

Preliminary study of neurofilament light chain as a biomarker for hypoxia-induced neuronal injury in dogs

Taesik Yun, Yeon Chae, Yoonhoi Koo, Dohee Lee, Hakhyun Kim, Mhan Pyo Yang, Byeong Teck Kang

Department of Veterinary Medicine

Chungbuk National University

Research output: Contribution to journal › Article › peer-review

Abstract

Neurofilament light chain (NfL) is a neuroaxonal protein in the nervous system. NfL has recently been demonstrated to be a biomarker for various neurological diseases. In this study, we investigated the potential role of NfL in hypoxia-induced neuronal injury in dogs. Serum NfL levels were determined using a single-molecule array. Serum NfL concentrations were significantly higher in hypoxemic dogs without neurological signs (n = 6, 175.5 pg/mL) than in healthy dogs (n = 15, 15.9 pg/mL; p < 0.0001). Therefore, neuronal injury should be considered in dogs with hypoxemia caused by cardiopulmonary diseases, even in the absence of neurological signs.

Original language	English
Article number	1284306
Journal	Frontiers in Veterinary Science
Volume	10
DOIs	https://doi.org/10.3389/fvets.2023.1284306
State	Published - 2023

Keywords

biomarker
canine
hypoxemia
ischemia
NfL

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10.3389/fvets.2023.1284306

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title = "Preliminary study of neurofilament light chain as a biomarker for hypoxia-induced neuronal injury in dogs",

abstract = "Neurofilament light chain (NfL) is a neuroaxonal protein in the nervous system. NfL has recently been demonstrated to be a biomarker for various neurological diseases. In this study, we investigated the potential role of NfL in hypoxia-induced neuronal injury in dogs. Serum NfL levels were determined using a single-molecule array. Serum NfL concentrations were significantly higher in hypoxemic dogs without neurological signs (n = 6, 175.5 pg/mL) than in healthy dogs (n = 15, 15.9 pg/mL; p < 0.0001). Therefore, neuronal injury should be considered in dogs with hypoxemia caused by cardiopulmonary diseases, even in the absence of neurological signs.",

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AU - Yun, Taesik

AU - Chae, Yeon

AU - Koo, Yoonhoi

AU - Lee, Dohee

AU - Kim, Hakhyun

AU - Yang, Mhan Pyo

AU - Kang, Byeong Teck

PY - 2023

Y1 - 2023

N2 - Neurofilament light chain (NfL) is a neuroaxonal protein in the nervous system. NfL has recently been demonstrated to be a biomarker for various neurological diseases. In this study, we investigated the potential role of NfL in hypoxia-induced neuronal injury in dogs. Serum NfL levels were determined using a single-molecule array. Serum NfL concentrations were significantly higher in hypoxemic dogs without neurological signs (n = 6, 175.5 pg/mL) than in healthy dogs (n = 15, 15.9 pg/mL; p < 0.0001). Therefore, neuronal injury should be considered in dogs with hypoxemia caused by cardiopulmonary diseases, even in the absence of neurological signs.

AB - Neurofilament light chain (NfL) is a neuroaxonal protein in the nervous system. NfL has recently been demonstrated to be a biomarker for various neurological diseases. In this study, we investigated the potential role of NfL in hypoxia-induced neuronal injury in dogs. Serum NfL levels were determined using a single-molecule array. Serum NfL concentrations were significantly higher in hypoxemic dogs without neurological signs (n = 6, 175.5 pg/mL) than in healthy dogs (n = 15, 15.9 pg/mL; p < 0.0001). Therefore, neuronal injury should be considered in dogs with hypoxemia caused by cardiopulmonary diseases, even in the absence of neurological signs.

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Preliminary study of neurofilament light chain as a biomarker for hypoxia-induced neuronal injury in dogs

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Keywords

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