Prenyl-flavonoids from Epimedium koreanum Nakai and their soluble epoxide hydrolase and tyrosinase inhibitory activities

Xiang Dong Su; Wei Li; Ji Eun Kim; Seo Young Yang; Jin Yeul Ma; Young Ho Kim

doi:10.1007/s00044-017-1975-x

Prenyl-flavonoids from Epimedium koreanum Nakai and their soluble epoxide hydrolase and tyrosinase inhibitory activities

Xiang Dong Su, Wei Li, Ji Eun Kim, Seo Young Yang, Jin Yeul Ma, Young Ho Kim

Department of Biology Education

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

A new 8-prenyl-flavonoid, epimedokoreanoside III, and 11 other flavonoids, were isolated from the aerial parts of Epimedium koreanum Nakai. Their chemical structures were elucidated by nuclear magnetic resonance and mass analyzes. All isolates were evaluated for their soluble epoxide hydrolase and tyrosinase inhibitory activities. Among the isolates, compounds 1, 5, 9, 10, and 12 exerted soluble epoxide hydrolase inhibitory activity in dose-dependent manner, with IC₅₀ values ranging from 26.0 ± 1.2 to 37.6 ± 1.0 µM, whereas compounds 4 and 9 showed potent inhibition of tyrosinase in a dose-dependent manner, having IC₅₀ values of 16.8 ± 2.7 and 8.7 ± 2.7 µM, respectively.

Original language	English
Pages (from-to)	2761-2767
Number of pages	7
Journal	Medicinal Chemistry Research
Volume	26
Issue number	11
DOIs	https://doi.org/10.1007/s00044-017-1975-x
State	Published - 1 Nov 2017

Keywords

Berberidaceae
Epimedium koreanum Nakai
Flavonoids
Soluble epoxide hydrolase
Tyrosinase

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title = "Prenyl-flavonoids from Epimedium koreanum Nakai and their soluble epoxide hydrolase and tyrosinase inhibitory activities",

abstract = "A new 8-prenyl-flavonoid, epimedokoreanoside III, and 11 other flavonoids, were isolated from the aerial parts of Epimedium koreanum Nakai. Their chemical structures were elucidated by nuclear magnetic resonance and mass analyzes. All isolates were evaluated for their soluble epoxide hydrolase and tyrosinase inhibitory activities. Among the isolates, compounds 1, 5, 9, 10, and 12 exerted soluble epoxide hydrolase inhibitory activity in dose-dependent manner, with IC50 values ranging from 26.0 ± 1.2 to 37.6 ± 1.0 µM, whereas compounds 4 and 9 showed potent inhibition of tyrosinase in a dose-dependent manner, having IC50 values of 16.8 ± 2.7 and 8.7 ± 2.7 µM, respectively.",

keywords = "Berberidaceae, Epimedium koreanum Nakai, Flavonoids, Soluble epoxide hydrolase, Tyrosinase",

author = "{Dong Su}, Xiang and Wei Li and {Eun Kim}, Ji and {Young Yang}, Seo and {Yeul Ma}, Jin and {Ho Kim}, Young",

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year = "2017",

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doi = "10.1007/s00044-017-1975-x",

language = "English",

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journal = "Medicinal Chemistry Research",

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TY - JOUR

T1 - Prenyl-flavonoids from Epimedium koreanum Nakai and their soluble epoxide hydrolase and tyrosinase inhibitory activities

AU - Dong Su, Xiang

AU - Li, Wei

AU - Eun Kim, Ji

AU - Young Yang, Seo

AU - Yeul Ma, Jin

AU - Ho Kim, Young

PY - 2017/11/1

Y1 - 2017/11/1

N2 - A new 8-prenyl-flavonoid, epimedokoreanoside III, and 11 other flavonoids, were isolated from the aerial parts of Epimedium koreanum Nakai. Their chemical structures were elucidated by nuclear magnetic resonance and mass analyzes. All isolates were evaluated for their soluble epoxide hydrolase and tyrosinase inhibitory activities. Among the isolates, compounds 1, 5, 9, 10, and 12 exerted soluble epoxide hydrolase inhibitory activity in dose-dependent manner, with IC50 values ranging from 26.0 ± 1.2 to 37.6 ± 1.0 µM, whereas compounds 4 and 9 showed potent inhibition of tyrosinase in a dose-dependent manner, having IC50 values of 16.8 ± 2.7 and 8.7 ± 2.7 µM, respectively.

AB - A new 8-prenyl-flavonoid, epimedokoreanoside III, and 11 other flavonoids, were isolated from the aerial parts of Epimedium koreanum Nakai. Their chemical structures were elucidated by nuclear magnetic resonance and mass analyzes. All isolates were evaluated for their soluble epoxide hydrolase and tyrosinase inhibitory activities. Among the isolates, compounds 1, 5, 9, 10, and 12 exerted soluble epoxide hydrolase inhibitory activity in dose-dependent manner, with IC50 values ranging from 26.0 ± 1.2 to 37.6 ± 1.0 µM, whereas compounds 4 and 9 showed potent inhibition of tyrosinase in a dose-dependent manner, having IC50 values of 16.8 ± 2.7 and 8.7 ± 2.7 µM, respectively.

KW - Berberidaceae

KW - Epimedium koreanum Nakai

KW - Flavonoids

KW - Soluble epoxide hydrolase

KW - Tyrosinase

UR - http://www.scopus.com/inward/record.url?scp=85028766746&partnerID=8YFLogxK

U2 - 10.1007/s00044-017-1975-x

DO - 10.1007/s00044-017-1975-x

M3 - Article

AN - SCOPUS:85028766746

SN - 1054-2523

VL - 26

SP - 2761

EP - 2767

JO - Medicinal Chemistry Research

JF - Medicinal Chemistry Research

IS - 11

ER -

Prenyl-flavonoids from Epimedium koreanum Nakai and their soluble epoxide hydrolase and tyrosinase inhibitory activities

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Keywords

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