Prenylated flavonoids from the roots of Sophora flavescens with tyrosinase inhibitory activity

Jong Keun Son; Ji Soo Park; Jeong Ah Kim; Youngsoo Kim; See Ryun Chung; Seung Ho Lee

doi:10.1055/s-2003-40643

Prenylated flavonoids from the roots of Sophora flavescens with tyrosinase inhibitory activity

Jong Keun Son, Ji Soo Park, Jeong Ah Kim, Youngsoo Kim, See Ryun Chung, Seung Ho Lee

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Abstract

Prenylated flavonoids containing the resorcinol moiety were isolated as tyrosinase inhibitors from the roots of Sophora flavescens by activity-guided fractionation. Among the 12 compounds isolated, kuraridin, kurarinone and norkurarinol showed stronger inhibitory potencies (IC₅₀ = 1.1, 1.3 and 2.1 μM, respectively) than that of kojic acid (1C₅₀ = 11.3 μM), a well known tyrosinase inhibitor. Substitution of a lavandulyl or hydroxylavandulyl group at the C-8 position and a methoxy or hydroxy group at the C-5 position are essential for the inhibitory effect.

Original language	English
Pages (from-to)	559-561
Number of pages	3
Journal	Planta Medica
Volume	69
Issue number	6
DOIs	https://doi.org/10.1055/s-2003-40643
State	Published - 1 Jun 2003

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abstract = "Prenylated flavonoids containing the resorcinol moiety were isolated as tyrosinase inhibitors from the roots of Sophora flavescens by activity-guided fractionation. Among the 12 compounds isolated, kuraridin, kurarinone and norkurarinol showed stronger inhibitory potencies (IC50 = 1.1, 1.3 and 2.1 μM, respectively) than that of kojic acid (1C50 = 11.3 μM), a well known tyrosinase inhibitor. Substitution of a lavandulyl or hydroxylavandulyl group at the C-8 position and a methoxy or hydroxy group at the C-5 position are essential for the inhibitory effect.",

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T1 - Prenylated flavonoids from the roots of Sophora flavescens with tyrosinase inhibitory activity

AU - Son, Jong Keun

AU - Park, Ji Soo

AU - Kim, Jeong Ah

AU - Kim, Youngsoo

AU - Chung, See Ryun

AU - Lee, Seung Ho

PY - 2003/6/1

Y1 - 2003/6/1

N2 - Prenylated flavonoids containing the resorcinol moiety were isolated as tyrosinase inhibitors from the roots of Sophora flavescens by activity-guided fractionation. Among the 12 compounds isolated, kuraridin, kurarinone and norkurarinol showed stronger inhibitory potencies (IC50 = 1.1, 1.3 and 2.1 μM, respectively) than that of kojic acid (1C50 = 11.3 μM), a well known tyrosinase inhibitor. Substitution of a lavandulyl or hydroxylavandulyl group at the C-8 position and a methoxy or hydroxy group at the C-5 position are essential for the inhibitory effect.

AB - Prenylated flavonoids containing the resorcinol moiety were isolated as tyrosinase inhibitors from the roots of Sophora flavescens by activity-guided fractionation. Among the 12 compounds isolated, kuraridin, kurarinone and norkurarinol showed stronger inhibitory potencies (IC50 = 1.1, 1.3 and 2.1 μM, respectively) than that of kojic acid (1C50 = 11.3 μM), a well known tyrosinase inhibitor. Substitution of a lavandulyl or hydroxylavandulyl group at the C-8 position and a methoxy or hydroxy group at the C-5 position are essential for the inhibitory effect.

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SP - 559

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JO - Planta Medica

JF - Planta Medica

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ER -

Prenylated flavonoids from the roots of Sophora flavescens with tyrosinase inhibitory activity

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