Prenylated flavonoids from the roots of Sophora flavescens with tyrosinase inhibitory activity

Jong Keun Son; Ji Soo Park; Jeong Ah Kim; Youngsoo Kim; See Ryun Chung; Seung Ho Lee

doi:10.1055/s-2003-40643

Prenylated flavonoids from the roots of Sophora flavescens with tyrosinase inhibitory activity

Jong Keun Son
, Ji Soo Park
, Jeong Ah Kim
, Youngsoo Kim
, See Ryun Chung
, Seung Ho Lee

Yeungnam University
Chungbuk National University

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

Prenylated flavonoids containing the resorcinol moiety were isolated as tyrosinase inhibitors from the roots of Sophora flavescens by activity-guided fractionation. Among the 12 compounds isolated, kuraridin, kurarinone and norkurarinol showed stronger inhibitory potencies (IC₅₀ = 1.1, 1.3 and 2.1 μM, respectively) than that of kojic acid (1C₅₀ = 11.3 μM), a well known tyrosinase inhibitor. Substitution of a lavandulyl or hydroxylavandulyl group at the C-8 position and a methoxy or hydroxy group at the C-5 position are essential for the inhibitory effect.

Original language	English
Pages (from-to)	559-561
Number of pages	3
Journal	Planta Medica
Volume	69
Issue number	6
DOIs	https://doi.org/10.1055/s-2003-40643
State	Published - 1 Jun 2003

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title = "Prenylated flavonoids from the roots of Sophora flavescens with tyrosinase inhibitory activity",

abstract = "Prenylated flavonoids containing the resorcinol moiety were isolated as tyrosinase inhibitors from the roots of Sophora flavescens by activity-guided fractionation. Among the 12 compounds isolated, kuraridin, kurarinone and norkurarinol showed stronger inhibitory potencies (IC50 = 1.1, 1.3 and 2.1 μM, respectively) than that of kojic acid (1C50 = 11.3 μM), a well known tyrosinase inhibitor. Substitution of a lavandulyl or hydroxylavandulyl group at the C-8 position and a methoxy or hydroxy group at the C-5 position are essential for the inhibitory effect.",

author = "Son, \{Jong Keun\} and Park, \{Ji Soo\} and Kim, \{Jeong Ah\} and Youngsoo Kim and Chung, \{See Ryun\} and Lee, \{Seung Ho\}",

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T1 - Prenylated flavonoids from the roots of Sophora flavescens with tyrosinase inhibitory activity

AU - Son, Jong Keun

AU - Park, Ji Soo

AU - Kim, Jeong Ah

AU - Kim, Youngsoo

AU - Chung, See Ryun

AU - Lee, Seung Ho

PY - 2003/6/1

Y1 - 2003/6/1

N2 - Prenylated flavonoids containing the resorcinol moiety were isolated as tyrosinase inhibitors from the roots of Sophora flavescens by activity-guided fractionation. Among the 12 compounds isolated, kuraridin, kurarinone and norkurarinol showed stronger inhibitory potencies (IC50 = 1.1, 1.3 and 2.1 μM, respectively) than that of kojic acid (1C50 = 11.3 μM), a well known tyrosinase inhibitor. Substitution of a lavandulyl or hydroxylavandulyl group at the C-8 position and a methoxy or hydroxy group at the C-5 position are essential for the inhibitory effect.

AB - Prenylated flavonoids containing the resorcinol moiety were isolated as tyrosinase inhibitors from the roots of Sophora flavescens by activity-guided fractionation. Among the 12 compounds isolated, kuraridin, kurarinone and norkurarinol showed stronger inhibitory potencies (IC50 = 1.1, 1.3 and 2.1 μM, respectively) than that of kojic acid (1C50 = 11.3 μM), a well known tyrosinase inhibitor. Substitution of a lavandulyl or hydroxylavandulyl group at the C-8 position and a methoxy or hydroxy group at the C-5 position are essential for the inhibitory effect.

UR - https://www.scopus.com/pages/publications/0037826011

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DO - 10.1055/s-2003-40643

M3 - Article

C2 - 12865979

AN - SCOPUS:0037826011

SN - 0032-0943

VL - 69

SP - 559

EP - 561

JO - Planta Medica

JF - Planta Medica

IS - 6

ER -

Prenylated flavonoids from the roots of Sophora flavescens with tyrosinase inhibitory activity

Abstract

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