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Preparation and characterization of release behavior for hydrophilic dung loaded alginate nanohydrogels

  • S. M. Lee
  • , H. Y. Lee
  • , Y. M. Kim
  • , M. K. Kim
  • , S. O. Sohn
  • , H. D. Ghim

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

4 Scopus citations

Abstract

Recently, there have been considerable interests in developing biodegradable nanoparticles as effective drug delivery devices. Alginate is one of the hydrophilic natural polymers having biodegradability and biocompatibility. It has possibility to apply in the controlled release of drugs, targeting particular organs/tissues, as carrier of DNA in gene therapy, and delivery proteins and peptides through a peroral route of administration. In this work, we proposed reverse emulsification-diffusion method to prepare alginate nanohydrogels containing hydrophilic drug and studied various parameters to influence in preparation of them. Physicochemical characteristics and in vitro release behavior of hydrophilic drug loaded alginate nanohydrogels were also investigated to establish them as a novel carrier for controlled release drug delivery system.

Original languageEnglish
Title of host publication2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings
Pages250-253
Number of pages4
StatePublished - 2007
Event2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007 - Santa Clara, CA, United States
Duration: 20 May 200724 May 2007

Publication series

Name2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings
Volume4

Conference

Conference2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007
Country/TerritoryUnited States
CitySanta Clara, CA
Period20/05/0724/05/07

Keywords

  • Alginate nanohydrogels
  • Controlled release
  • Hydrophilic drug
  • Reverse emulsification-diffusion method

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