Preparation of antimicrobial sodium alginate with chito-oligosaccharide side chains

Jae Wook Song; Han Do Ghim; Jin Hyun Choi; Sohk Won Ko; Won Seok Lyoo

doi:10.1002/pola.1158

Preparation of antimicrobial sodium alginate with chito-oligosaccharide side chains

Jae Wook Song, Han Do Ghim, Jin Hyun Choi, Sohk Won Ko, Won Seok Lyoo

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

To provide sodium alginate (SA) with an antimicrobial property, we introduced chito-oligosaccharide (COS) via chemical bonding in a two-step procedure. We reacted COS with N-methylol acrylamide (NMA) with N-methylol groups to prepare acrylamidomethyl chito-oligosaccharide (COS-NMA). SA with COS side chains (SACOS) was produced through a subsequent reaction of SA with COS-NMA. The chemical structure of SA-COS was confirmed by IR spectroscopy and ¹H NMR spectroscopy. With a two-step method, we successfully prevented insoluble-complex formation due to electrostatic attraction between chitosan and alginate. SA-COS showed excellent antimicrobial activity, with the growth of microorganisms completely suppressed by a small amount of COS (1.8 wt %).

Original language	English
Pages (from-to)	1810-1816
Number of pages	7
Journal	Journal of Polymer Science, Part A: Polymer Chemistry
Volume	39
Issue number	10
DOIs	https://doi.org/10.1002/pola.1158
State	Published - 15 May 2001

Keywords

Antimicrobial activity
Chito-oligosaccharide
N-methylol acrylamide
Sodium alginate

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10.1002/pola.1158

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title = "Preparation of antimicrobial sodium alginate with chito-oligosaccharide side chains",

abstract = "To provide sodium alginate (SA) with an antimicrobial property, we introduced chito-oligosaccharide (COS) via chemical bonding in a two-step procedure. We reacted COS with N-methylol acrylamide (NMA) with N-methylol groups to prepare acrylamidomethyl chito-oligosaccharide (COS-NMA). SA with COS side chains (SACOS) was produced through a subsequent reaction of SA with COS-NMA. The chemical structure of SA-COS was confirmed by IR spectroscopy and 1H NMR spectroscopy. With a two-step method, we successfully prevented insoluble-complex formation due to electrostatic attraction between chitosan and alginate. SA-COS showed excellent antimicrobial activity, with the growth of microorganisms completely suppressed by a small amount of COS (1.8 wt %).",

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AU - Song, Jae Wook

AU - Ghim, Han Do

AU - Choi, Jin Hyun

AU - Ko, Sohk Won

AU - Lyoo, Won Seok

PY - 2001/5/15

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AB - To provide sodium alginate (SA) with an antimicrobial property, we introduced chito-oligosaccharide (COS) via chemical bonding in a two-step procedure. We reacted COS with N-methylol acrylamide (NMA) with N-methylol groups to prepare acrylamidomethyl chito-oligosaccharide (COS-NMA). SA with COS side chains (SACOS) was produced through a subsequent reaction of SA with COS-NMA. The chemical structure of SA-COS was confirmed by IR spectroscopy and 1H NMR spectroscopy. With a two-step method, we successfully prevented insoluble-complex formation due to electrostatic attraction between chitosan and alginate. SA-COS showed excellent antimicrobial activity, with the growth of microorganisms completely suppressed by a small amount of COS (1.8 wt %).

KW - Antimicrobial activity

KW - Chito-oligosaccharide

KW - N-methylol acrylamide

KW - Sodium alginate

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JO - Journal of Polymer Science, Part A: Polymer Chemistry

JF - Journal of Polymer Science, Part A: Polymer Chemistry

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Preparation of antimicrobial sodium alginate with chito-oligosaccharide side chains

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