Abstract
Optically active epoxy alcohol, (R)-2-butyryloxymethylglycidol3 which is the precursor of a tert-alcohol chiral building block was obtained in high enantiomeric purity, 98.7% e.e., by lipase-catalyzed asymmetric hydrolysis using a phosphate buffer and organic co-solvent system in 95% of chemical yield.
Original language | English |
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Pages (from-to) | 3009-3014 |
Number of pages | 6 |
Journal | Tetrahedron Asymmetry |
Volume | 6 |
Issue number | 12 |
DOIs | |
State | Published - Dec 1995 |