Preparation of enantiomerically pure (R)-2-butyryloxymethylglycidol by lipase-catalyzed asymmetric hydrolysis

Young Bae Seu, Taeg Kyeong Lim, Chang Jin Kim, Sun Chul Kang

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Abstract

Optically active epoxy alcohol, (R)-2-butyryloxymethylglycidol3 which is the precursor of a tert-alcohol chiral building block was obtained in high enantiomeric purity, 98.7% e.e., by lipase-catalyzed asymmetric hydrolysis using a phosphate buffer and organic co-solvent system in 95% of chemical yield.

Original languageEnglish
Pages (from-to)3009-3014
Number of pages6
JournalTetrahedron Asymmetry
Volume6
Issue number12
DOIs
StatePublished - Dec 1995

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