Preparation of enantiomerically pure (R)-2-butyryloxymethylglycidol by lipase-catalyzed asymmetric hydrolysis

Young Bae Seu; Taeg Kyeong Lim; Chang Jin Kim; Sun Chul Kang

doi:10.1016/0957-4166(95)00397-5

Preparation of enantiomerically pure (R)-2-butyryloxymethylglycidol by lipase-catalyzed asymmetric hydrolysis

Young Bae Seu, Taeg Kyeong Lim, Chang Jin Kim, Sun Chul Kang

School of Life Science and Biotechnology

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Optically active epoxy alcohol, (R)-2-butyryloxymethylglycidol3 which is the precursor of a tert-alcohol chiral building block was obtained in high enantiomeric purity, 98.7% e.e., by lipase-catalyzed asymmetric hydrolysis using a phosphate buffer and organic co-solvent system in 95% of chemical yield.

Original language	English
Pages (from-to)	3009-3014
Number of pages	6
Journal	Tetrahedron Asymmetry
Volume	6
Issue number	12
DOIs	https://doi.org/10.1016/0957-4166(95)00397-5
State	Published - Dec 1995

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title = "Preparation of enantiomerically pure (R)-2-butyryloxymethylglycidol by lipase-catalyzed asymmetric hydrolysis",

abstract = "Optically active epoxy alcohol, (R)-2-butyryloxymethylglycidol3 which is the precursor of a tert-alcohol chiral building block was obtained in high enantiomeric purity, 98.7\% e.e., by lipase-catalyzed asymmetric hydrolysis using a phosphate buffer and organic co-solvent system in 95\% of chemical yield.",

author = "Seu, \{Young Bae\} and Lim, \{Taeg Kyeong\} and Kim, \{Chang Jin\} and Kang, \{Sun Chul\}",

year = "1995",

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doi = "10.1016/0957-4166(95)00397-5",

language = "English",

volume = "6",

pages = "3009--3014",

journal = "Tetrahedron Asymmetry",

issn = "0957-4166",

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T1 - Preparation of enantiomerically pure (R)-2-butyryloxymethylglycidol by lipase-catalyzed asymmetric hydrolysis

AU - Seu, Young Bae

AU - Lim, Taeg Kyeong

AU - Kim, Chang Jin

AU - Kang, Sun Chul

PY - 1995/12

Y1 - 1995/12

N2 - Optically active epoxy alcohol, (R)-2-butyryloxymethylglycidol3 which is the precursor of a tert-alcohol chiral building block was obtained in high enantiomeric purity, 98.7% e.e., by lipase-catalyzed asymmetric hydrolysis using a phosphate buffer and organic co-solvent system in 95% of chemical yield.

AB - Optically active epoxy alcohol, (R)-2-butyryloxymethylglycidol3 which is the precursor of a tert-alcohol chiral building block was obtained in high enantiomeric purity, 98.7% e.e., by lipase-catalyzed asymmetric hydrolysis using a phosphate buffer and organic co-solvent system in 95% of chemical yield.

UR - https://www.scopus.com/pages/publications/0029620773

U2 - 10.1016/0957-4166(95)00397-5

DO - 10.1016/0957-4166(95)00397-5

M3 - Article

AN - SCOPUS:0029620773

SN - 0957-4166

VL - 6

SP - 3009

EP - 3014

JO - Tetrahedron Asymmetry

JF - Tetrahedron Asymmetry

IS - 12

ER -

Preparation of enantiomerically pure (R)-2-butyryloxymethylglycidol by lipase-catalyzed asymmetric hydrolysis

Abstract

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