Preparation of lidocaine-loaded porous Poly (lactic-co-glycolic acid) microparticles using microfluidic flow focusing and phosphate buffer solution porogen

Chul Min Kim; Asad Ullah; Chul Ho Chang; Gyu Man Kim

doi:10.1007/s12541-017-0071-y

Preparation of lidocaine-loaded porous Poly (lactic-co-glycolic acid) microparticles using microfluidic flow focusing and phosphate buffer solution porogen

Chul Min Kim, Asad Ullah, Chul Ho Chang, Gyu Man Kim

School of Mechanical Engineering

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Local anesthesia is widely used in the treatment of postoperative pain. Long time duration and constant release of the local anesthetic is important for pain control. In this study, a preparation method of porous Poly (lactic-co-glycolic acid) (PLGA) microparticles loaded with local anesthetic, lidocaine was studied. Microfluidic flow-focusing device was used to prepare monodispersed microparticles. A phosphate buffer solution (PBS) was used as porogen. The geometry of microparticles was analyzed, and the drug release profile was determined by UV spectroscopy. Test results showed that porous microparticles are beneficial for sustained release of local anesthetic in long time duration over 40 days.

Original language	English
Pages (from-to)	599-604
Number of pages	6
Journal	International Journal of Precision Engineering and Manufacturing
Volume	18
Issue number	4
DOIs	https://doi.org/10.1007/s12541-017-0071-y
State	Published - 1 Apr 2017

Keywords

Drug delivery
Lidocaine
Local anesthesia
Microfluidic flow-focusing device
PLGA
Porous microparticle

Access to Document

10.1007/s12541-017-0071-y

Cite this

@article{26665131c31d43ab8d3bfadb25d9a22d,

title = "Preparation of lidocaine-loaded porous Poly (lactic-co-glycolic acid) microparticles using microfluidic flow focusing and phosphate buffer solution porogen",

abstract = "Local anesthesia is widely used in the treatment of postoperative pain. Long time duration and constant release of the local anesthetic is important for pain control. In this study, a preparation method of porous Poly (lactic-co-glycolic acid) (PLGA) microparticles loaded with local anesthetic, lidocaine was studied. Microfluidic flow-focusing device was used to prepare monodispersed microparticles. A phosphate buffer solution (PBS) was used as porogen. The geometry of microparticles was analyzed, and the drug release profile was determined by UV spectroscopy. Test results showed that porous microparticles are beneficial for sustained release of local anesthetic in long time duration over 40 days.",

keywords = "Drug delivery, Lidocaine, Local anesthesia, Microfluidic flow-focusing device, PLGA, Porous microparticle",

author = "Kim, {Chul Min} and Asad Ullah and Chang, {Chul Ho} and Kim, {Gyu Man}",

note = "Publisher Copyright: {\textcopyright} 2017, Korean Society for Precision Engineering and Springer-Verlag Berlin Heidelberg.",

year = "2017",

month = apr,

day = "1",

doi = "10.1007/s12541-017-0071-y",

language = "English",

volume = "18",

pages = "599--604",

journal = "International Journal of Precision Engineering and Manufacturing",

issn = "2234-7593",

publisher = "Korean Society of Precision Engineering",

number = "4",

}

Preparation of lidocaine-loaded porous Poly (lactic-co-glycolic acid) microparticles using microfluidic flow focusing and phosphate buffer solution porogen. / Kim, Chul Min; Ullah, Asad; Chang, Chul Ho et al.
In: International Journal of Precision Engineering and Manufacturing, Vol. 18, No. 4, 01.04.2017, p. 599-604.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Preparation of lidocaine-loaded porous Poly (lactic-co-glycolic acid) microparticles using microfluidic flow focusing and phosphate buffer solution porogen

AU - Kim, Chul Min

AU - Ullah, Asad

AU - Chang, Chul Ho

AU - Kim, Gyu Man

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Local anesthesia is widely used in the treatment of postoperative pain. Long time duration and constant release of the local anesthetic is important for pain control. In this study, a preparation method of porous Poly (lactic-co-glycolic acid) (PLGA) microparticles loaded with local anesthetic, lidocaine was studied. Microfluidic flow-focusing device was used to prepare monodispersed microparticles. A phosphate buffer solution (PBS) was used as porogen. The geometry of microparticles was analyzed, and the drug release profile was determined by UV spectroscopy. Test results showed that porous microparticles are beneficial for sustained release of local anesthetic in long time duration over 40 days.

AB - Local anesthesia is widely used in the treatment of postoperative pain. Long time duration and constant release of the local anesthetic is important for pain control. In this study, a preparation method of porous Poly (lactic-co-glycolic acid) (PLGA) microparticles loaded with local anesthetic, lidocaine was studied. Microfluidic flow-focusing device was used to prepare monodispersed microparticles. A phosphate buffer solution (PBS) was used as porogen. The geometry of microparticles was analyzed, and the drug release profile was determined by UV spectroscopy. Test results showed that porous microparticles are beneficial for sustained release of local anesthetic in long time duration over 40 days.

KW - Drug delivery

KW - Lidocaine

KW - Local anesthesia

KW - Microfluidic flow-focusing device

KW - PLGA

KW - Porous microparticle

UR - http://www.scopus.com/inward/record.url?scp=85017094899&partnerID=8YFLogxK

U2 - 10.1007/s12541-017-0071-y

DO - 10.1007/s12541-017-0071-y

M3 - Article

AN - SCOPUS:85017094899

SN - 2234-7593

VL - 18

SP - 599

EP - 604

JO - International Journal of Precision Engineering and Manufacturing

JF - International Journal of Precision Engineering and Manufacturing

IS - 4

ER -

Preparation of lidocaine-loaded porous Poly (lactic-co-glycolic acid) microparticles using microfluidic flow focusing and phosphate buffer solution porogen

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this