Preparation of new binaphthol derived chiral stationary phases

Yi Jun Zhang, Jae Jeong Ryoo

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

To develop more advanced binaphthol derived CSPs, two new 1,1-bi-2-naphthol derived chiral stationary phases (CSPs) (CSP 1 and CSP 2) were prepared by connecting with silica gel at a hydroxy (OH) group of binaphthol. Previously reported two 1,1'-binaphthyl-2,2'-diamine derived CSPs (CSP 3 and CSP 4) were also prepared to compare the role of their functional groups (-OH and -NH2) with CSP 1 and CSP 2. Enantioseparation of randomly selected, 11 chiral compounds on these four CSPs was performed and the results compared to each other. 3,5-Dinitrobenzoyl (3,5-DNB) derivatives of each CSP showed better results than the others and binaphthyldiamine derived CSP showed slightly better than binaphthol derived one.

Original languageEnglish
Pages (from-to)2756-2760
Number of pages5
JournalBulletin of the Korean Chemical Society
Volume32
Issue number8
DOIs
StatePublished - 20 Aug 2011

Keywords

  • Binaphthol chiral stationary phase
  • Enantioseparation

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