Pressure tolerant multilayered polymer film microfluidics by one-step bonding process for high throughput emulsion generation

Kyoung Ik Min, Dong Pyo Kim

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

We present a simple method for fabrication of a pressure tolerant multilayered 3D polyimide film microfluidic device for generating a high throughput oil-in-water emulsion. The device fabricated can withstand pressure up to approximately 70 bars and temperature up to 200 °C, and polyimide is inert to solvents and solutions, not causing problems such as swelling as with PDMS. The triple-layered microchannels fabricated by one-step bonding process of patterned and assembled thin films are demonstrated to produce monodisperse n-hexane droplets upto a generation rate of 200 kHz. Moreover, highly uniform PLGA micro- And nanoparticles were obtained using 3D flow focusing device without channel clogging.

Original languageEnglish
Title of host publicationProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
PublisherChemical and Biological Microsystems Society
Pages1798-1800
Number of pages3
ISBN (Print)9780979806452
StatePublished - 2012
Event16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 - Okinawa, Japan
Duration: 28 Oct 20121 Nov 2012

Publication series

NameProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012

Conference

Conference16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
Country/TerritoryJapan
CityOkinawa
Period28/10/121/11/12

Keywords

  • Droplet
  • High pressure
  • Multilayer
  • Polyimide film
  • Three dimension

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