Presynaptic PTPσ regulates postsynaptic NMDA receptor function through direct adhesion-independent mechanisms

Kyungdeok Kim, Wangyong Shin, Muwon Kang, Suho Lee, Doyoun Kim, Ryeonghwa Kang, Yewon Jung, Yisul Cho, Esther Yang, Hyun Kim, Yong Chul Bae, Eunjoon Kim

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17 Scopus citations


Synaptic adhesion molecules regulate synapse development and function. However, whether and how presynaptic adhesion molecules regulate postsynaptic NMDAR function remains largely unclear. Presynaptic LAR family receptor tyrosine phosphatases (LAR-RPTPs) regulate synapse development through mechanisms that include trans-synaptic adhesion; however, whether they regulate postsynaptic receptor functions remains unknown. Here we report that presynaptic PTPs, a LAR-RPTP, enhances postsynaptic NMDA receptor (NMDAR) currents and NMDAR-dependent synaptic plasticity in the hippocampus. This regulation does not involve trans-synaptic adhesions of PTPs, suggesting that the cytoplasmic domains of PTPs, known to have tyrosine phosphatase activity and mediate protein-protein interactions, are important. In line with this, phosphotyrosine levels of presynaptic proteins, including neurexin-1, are strongly increased in PTPs-mutant mice. Behaviorally, PTPs-dependent NMDAR regulation is important for social and reward-related novelty recognition. These results suggest that presynaptic PTPs regulates postsynaptic NMDAR function through trans-synaptic and direct adhesion-independent mechanisms and novelty recognition in social and reward contexts.

Original languageEnglish
Article numbere54224
StatePublished - Mar 2020


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