Prevalence and molecular analysis of glucose-6-phosphate dehydrogenase deficiency in Chin State, Myanmar

Ja Moon Aung, Zin Moon, Dorene Van Bik, Sylvatrie Danne Dinzouna-Boutamba, Sanghyun Lee, Zau Ring, Dong Il Chung, Yeonchul Hong, Youn Kyoung Goo

Research output: Contribution to journalArticlepeer-review

Abstract

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is caused by X-linked reces-sive disorderliness. It induces severe anemia when a patient with G6PD deficiency is ex-posed to oxidative stress that occurs with administration of an antimalarial drug, prima-quine. The distribution of G6PD deficiency remains unknown while primaquine has been used for malaria treatment in Myanmar. This study aimed to investigate the prevalence of G6PD deficiency and its variants in Chin State, Myanmar. Among 322 participants, 18 (11 males and 7 females) demonstrated a G6PD deficiency. Orissa variant was dominant in the molecular analysis. This would be related to neighboring Indian and Bangladeshi population, in which Orissa variant was also reported as the main mutation type. The screening test for G6PD deficiency before primaquine treatment appears to be impor-.

Original languageEnglish
Pages (from-to)154-162
Number of pages9
JournalParasites, Hosts and Diseases
Volume61
Issue number2
DOIs
StatePublished - May 2023

Keywords

  • Chin State
  • Glucose-6-phosphate dehydrogenase deficiency
  • Myanmar
  • variant

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