Procyanidins from the stem wood of Machilus japonica and their inhibitory effect on LDL oxidation

Hee Jung Park, Su Yeon Kim, Na Young Song, Jin Gyeong Cho, Ji Hyun Kang, Tae Sook Jeong, Dae Young Lee, Geum Soog Kim, Yong Bum Kim, Hee Cheol Kang, Nam In Baek

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4 Scopus citations

Abstract

The stem wood of Machilus japonica Siebold & Zucc were extracted with 80 % aqueous MeOH, and the concentrated extract was successively partitioned with ethyl acetate (EtOAc), normal butanol, and water. From the EtOAc fraction, five procyanidins, procyanidin A1 (1), procyanidin A2 (2), procyanidin B7 (3), cinnamtannin B1 (4), and aesculitannin B (5), were isolated. Their chemical structures were identified through spectroscopic data analyses including NMR, MS, and IR. This is the first time any of these compounds have been isolated from this plant. The compounds were evaluated for inhibition activity on LDL oxidation. All of these compounds and the positive control, BHT, showed a very high inhibition effect with IC50 values of 0.94, 2.1, 1.8, 1.1, 1.0, and 1.9 μM, respectively.

Original languageEnglish
Pages (from-to)1403-1410
Number of pages8
JournalArchives of Pharmacal Research
Volume37
Issue number11
DOIs
StatePublished - Nov 2014

Keywords

  • Low-density lipoprotein
  • Machilus japonica
  • Procyanidin

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