Production of a Ras farnesyl protein transferase inhibitor from Bacillus licheniformis using Plackett-Burman design

Kwang Hee Son, Su Hyung Hong, Yong Kook Kwon, Kyoung Sook Bae, Young Kook Kim, Byoung Mog Kwon, Sung Uk Kim, Song Hae Bok

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Compound CBR004 which inhibits Ras farnesyl protein transferase, was produced by Bacillus licheniformis KCTC0372BP. Potassium phosphate and Tryptone were selected as media components for the production of CBR004 among 6 culture-variables using Plackett-Burman design. The yield of CBR004 was 0.99 g/l in a stirred fermenter at the C/N ratio of 1.87.

Original languageEnglish
Pages (from-to)149-151
Number of pages3
JournalBiotechnology Letters
Volume20
Issue number2
DOIs
StatePublished - 1998

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