Production of a Ras farnesyl protein transferase inhibitor from Bacillus licheniformis using Plackett-Burman design

Kwang Hee Son; Su Hyung Hong; Yong Kook Kwon; Kyoung Sook Bae; Young Kook Kim; Byoung Mog Kwon; Sung Uk Kim; Song Hae Bok

doi:10.1023/A:1005324407319

Production of a Ras farnesyl protein transferase inhibitor from Bacillus licheniformis using Plackett-Burman design

Kwang Hee Son, Su Hyung Hong, Yong Kook Kwon, Kyoung Sook Bae, Young Kook Kim, Byoung Mog Kwon, Sung Uk Kim, Song Hae Bok

Department of Dentistry

Korea Institute of Science and Technology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Compound CBR004 which inhibits Ras farnesyl protein transferase, was produced by Bacillus licheniformis KCTC0372BP. Potassium phosphate and Tryptone were selected as media components for the production of CBR004 among 6 culture-variables using Plackett-Burman design. The yield of CBR004 was 0.99 g/l in a stirred fermenter at the C/N ratio of 1.87.

Original language	English
Pages (from-to)	149-151
Number of pages	3
Journal	Biotechnology Letters
Volume	20
Issue number	2
DOIs	https://doi.org/10.1023/A:1005324407319
State	Published - 1998

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title = "Production of a Ras farnesyl protein transferase inhibitor from Bacillus licheniformis using Plackett-Burman design",

abstract = "Compound CBR004 which inhibits Ras farnesyl protein transferase, was produced by Bacillus licheniformis KCTC0372BP. Potassium phosphate and Tryptone were selected as media components for the production of CBR004 among 6 culture-variables using Plackett-Burman design. The yield of CBR004 was 0.99 g/l in a stirred fermenter at the C/N ratio of 1.87.",

author = "Son, \{Kwang Hee\} and Hong, \{Su Hyung\} and Kwon, \{Yong Kook\} and Bae, \{Kyoung Sook\} and Kim, \{Young Kook\} and Kwon, \{Byoung Mog\} and Kim, \{Sung Uk\} and Bok, \{Song Hae\}",

year = "1998",

doi = "10.1023/A:1005324407319",

language = "English",

volume = "20",

pages = "149--151",

journal = "Biotechnology Letters",

issn = "0141-5492",

publisher = "Springer Science and Business Media B.V.",

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TY - JOUR

T1 - Production of a Ras farnesyl protein transferase inhibitor from Bacillus licheniformis using Plackett-Burman design

AU - Son, Kwang Hee

AU - Hong, Su Hyung

AU - Kwon, Yong Kook

AU - Bae, Kyoung Sook

AU - Kim, Young Kook

AU - Kwon, Byoung Mog

AU - Kim, Sung Uk

AU - Bok, Song Hae

PY - 1998

Y1 - 1998

N2 - Compound CBR004 which inhibits Ras farnesyl protein transferase, was produced by Bacillus licheniformis KCTC0372BP. Potassium phosphate and Tryptone were selected as media components for the production of CBR004 among 6 culture-variables using Plackett-Burman design. The yield of CBR004 was 0.99 g/l in a stirred fermenter at the C/N ratio of 1.87.

AB - Compound CBR004 which inhibits Ras farnesyl protein transferase, was produced by Bacillus licheniformis KCTC0372BP. Potassium phosphate and Tryptone were selected as media components for the production of CBR004 among 6 culture-variables using Plackett-Burman design. The yield of CBR004 was 0.99 g/l in a stirred fermenter at the C/N ratio of 1.87.

UR - https://www.scopus.com/pages/publications/0031885733

U2 - 10.1023/A:1005324407319

DO - 10.1023/A:1005324407319

M3 - Article

AN - SCOPUS:0031885733

SN - 0141-5492

VL - 20

SP - 149

EP - 151

JO - Biotechnology Letters

JF - Biotechnology Letters

IS - 2

ER -

Production of a Ras farnesyl protein transferase inhibitor from Bacillus licheniformis using Plackett-Burman design

Abstract

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