Prognostic impact of microRNA-related gene polymorphisms on survival of patients with colorectal cancer

Hyun Chul Lee; Jong Gwang Kim; Yee Soo Chae; Sang Kyun Sohn; Byung Woog Kang; Joon Ho Moon; Seong Woo Jeon; Myung Hoon Lee; Kyoung Hoon Lim; Jin Young Park; Gyu Seog Choi; Soo Han Jun

doi:10.1007/s00432-009-0754-6

Prognostic impact of microRNA-related gene polymorphisms on survival of patients with colorectal cancer

Hyun Chul Lee, Jong Gwang Kim, Yee Soo Chae, Sang Kyun Sohn, Byung Woog Kang, Joon Ho Moon, Seong Woo Jeon, Myung Hoon Lee, Kyoung Hoon Lim, Jin Young Park, Gyu Seog Choi, Soo Han Jun

Department of Medicine

Kyungpook National University

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

Purpose: The polymorphisms in microRNA (miRNA) machinery genes and miRNA-containing genomic regions may play an important role in cancer development and prognosis. Accordingly, the present study analyzed the single nucleotide polymorphisms (SNPs) of miRNA-related genes and their impact on the prognosis for patients with colorectal cancer. Methods: Four hundred and twenty-six consecutive patients with surgically treated colorectal adenocarcinoma were enrolled. The genomic DNA was extracted from fresh colorectal tissue and 40 polymorphisms of miRNA-related genes determined using a real-time PCR genotyping assay. Results: In a univariate analysis, the progression-free survival of the patients with the combined mir492 C/G and G/G genotype was significantly worse than that of the patients with the mir492 C/C genotype (rs2289030) (P value = 0.0426), although there was no difference in the overall survival. However, no association was noted between the SNPs of the miRNA-related genes evaluated and survival in a multivariate analysis. Conclusions: None of the 40 miRNA-related gene polymorphisms investigated in this study was found to be an independent prognostic marker for Korean patients with surgically resected colorectal cancer. However, further studies are warranted to clarify the role of miRNA-related gene polymorphisms as a prognostic biomarker for colorectal cancer patients.

Original language	English
Pages (from-to)	1073-1078
Number of pages	6
Journal	Journal of Cancer Research and Clinical Oncology
Volume	136
Issue number	7
DOIs	https://doi.org/10.1007/s00432-009-0754-6
State	Published - Jul 2010

Keywords

Colorectal cancer
MiRNA
Polymorphism
Prognosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00432-009-0754-6

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Lee, H. C., Kim, J. G., Chae, Y. S., Sohn, S. K., Kang, B. W., Moon, J. H., Jeon, S. W., Lee, M. H., Lim, K. H., Park, J. Y., Choi, G. S., & Jun, S. H. (2010). Prognostic impact of microRNA-related gene polymorphisms on survival of patients with colorectal cancer. Journal of Cancer Research and Clinical Oncology, 136(7), 1073-1078. https://doi.org/10.1007/s00432-009-0754-6

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abstract = "Purpose: The polymorphisms in microRNA (miRNA) machinery genes and miRNA-containing genomic regions may play an important role in cancer development and prognosis. Accordingly, the present study analyzed the single nucleotide polymorphisms (SNPs) of miRNA-related genes and their impact on the prognosis for patients with colorectal cancer. Methods: Four hundred and twenty-six consecutive patients with surgically treated colorectal adenocarcinoma were enrolled. The genomic DNA was extracted from fresh colorectal tissue and 40 polymorphisms of miRNA-related genes determined using a real-time PCR genotyping assay. Results: In a univariate analysis, the progression-free survival of the patients with the combined mir492 C/G and G/G genotype was significantly worse than that of the patients with the mir492 C/C genotype (rs2289030) (P value = 0.0426), although there was no difference in the overall survival. However, no association was noted between the SNPs of the miRNA-related genes evaluated and survival in a multivariate analysis. Conclusions: None of the 40 miRNA-related gene polymorphisms investigated in this study was found to be an independent prognostic marker for Korean patients with surgically resected colorectal cancer. However, further studies are warranted to clarify the role of miRNA-related gene polymorphisms as a prognostic biomarker for colorectal cancer patients.",

keywords = "Colorectal cancer, MiRNA, Polymorphism, Prognosis",

author = "Lee, {Hyun Chul} and Kim, {Jong Gwang} and Chae, {Yee Soo} and Sohn, {Sang Kyun} and Kang, {Byung Woog} and Moon, {Joon Ho} and Jeon, {Seong Woo} and Lee, {Myung Hoon} and Lim, {Kyoung Hoon} and Park, {Jin Young} and Choi, {Gyu Seog} and Jun, {Soo Han}",

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doi = "10.1007/s00432-009-0754-6",

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T1 - Prognostic impact of microRNA-related gene polymorphisms on survival of patients with colorectal cancer

AU - Lee, Hyun Chul

AU - Kim, Jong Gwang

AU - Chae, Yee Soo

AU - Sohn, Sang Kyun

AU - Kang, Byung Woog

AU - Moon, Joon Ho

AU - Jeon, Seong Woo

AU - Lee, Myung Hoon

AU - Lim, Kyoung Hoon

AU - Park, Jin Young

AU - Choi, Gyu Seog

AU - Jun, Soo Han

PY - 2010/7

Y1 - 2010/7

N2 - Purpose: The polymorphisms in microRNA (miRNA) machinery genes and miRNA-containing genomic regions may play an important role in cancer development and prognosis. Accordingly, the present study analyzed the single nucleotide polymorphisms (SNPs) of miRNA-related genes and their impact on the prognosis for patients with colorectal cancer. Methods: Four hundred and twenty-six consecutive patients with surgically treated colorectal adenocarcinoma were enrolled. The genomic DNA was extracted from fresh colorectal tissue and 40 polymorphisms of miRNA-related genes determined using a real-time PCR genotyping assay. Results: In a univariate analysis, the progression-free survival of the patients with the combined mir492 C/G and G/G genotype was significantly worse than that of the patients with the mir492 C/C genotype (rs2289030) (P value = 0.0426), although there was no difference in the overall survival. However, no association was noted between the SNPs of the miRNA-related genes evaluated and survival in a multivariate analysis. Conclusions: None of the 40 miRNA-related gene polymorphisms investigated in this study was found to be an independent prognostic marker for Korean patients with surgically resected colorectal cancer. However, further studies are warranted to clarify the role of miRNA-related gene polymorphisms as a prognostic biomarker for colorectal cancer patients.

AB - Purpose: The polymorphisms in microRNA (miRNA) machinery genes and miRNA-containing genomic regions may play an important role in cancer development and prognosis. Accordingly, the present study analyzed the single nucleotide polymorphisms (SNPs) of miRNA-related genes and their impact on the prognosis for patients with colorectal cancer. Methods: Four hundred and twenty-six consecutive patients with surgically treated colorectal adenocarcinoma were enrolled. The genomic DNA was extracted from fresh colorectal tissue and 40 polymorphisms of miRNA-related genes determined using a real-time PCR genotyping assay. Results: In a univariate analysis, the progression-free survival of the patients with the combined mir492 C/G and G/G genotype was significantly worse than that of the patients with the mir492 C/C genotype (rs2289030) (P value = 0.0426), although there was no difference in the overall survival. However, no association was noted between the SNPs of the miRNA-related genes evaluated and survival in a multivariate analysis. Conclusions: None of the 40 miRNA-related gene polymorphisms investigated in this study was found to be an independent prognostic marker for Korean patients with surgically resected colorectal cancer. However, further studies are warranted to clarify the role of miRNA-related gene polymorphisms as a prognostic biomarker for colorectal cancer patients.

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KW - MiRNA

KW - Polymorphism

KW - Prognosis

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Prognostic impact of microRNA-related gene polymorphisms on survival of patients with colorectal cancer

Abstract

Keywords

UN SDGs

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