Prognostic impact of polymorphisms in the CASPASE genes on survival of patients with colorectal cancer

Jun Young Choi; Jong Gwang Kim; You Jin Lee; Yee Soo Chae; Sang Kyun Sohn; Joon Ho Moon; Byung Woog Kang; Min Kyu Jung; Seong Woo Jeon; Jun Seok Park; Gyu Seog Choi

doi:10.4143/crt.2012.44.1.32

Prognostic impact of polymorphisms in the CASPASE genes on survival of patients with colorectal cancer

Jun Young Choi, Jong Gwang Kim, You Jin Lee, Yee Soo Chae, Sang Kyun Sohn, Joon Ho Moon, Byung Woog Kang, Min Kyu Jung, Seong Woo Jeon, Jun Seok Park, Gyu Seog Choi

Department of Medicine

Kyungpook National University

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Purpose This study analyzed potentially functional polymorphisms in CASPASE (CASP) genes and their impact on the prognosis for Korean colorectal cancer patients. Materials and Methods A total of 397 consecutive patients with curatively resected colorectal adenocarcinoma were enrolled in this study. Genomic DNA from these patients was extracted from fresh colorectal tissue, and the 10 polymorphisms in the CASP3, CASP6, CASP7, CASP8, CASP9, and CASP10 genes were determined using a reverse transcription polymerase chain reaction genotyping assay. Results The median patient age was 63 years, and 218 (54.9%) patients had colon cancer, while 179 (45.1%) patients had rectal cancer. Univariate and multivariate survival analysis including pathologic stage, patient age, differentiation, and carcinoembryonic antigen level demonstrated that these polymorphisms were not associated with either disease-free or overall survival. Conclusion None of the 10 polymorphisms in the CASP genes investigated in this study was found to be an independent prognostic marker for Korean patients with curatively resected colorectal cancer.

Original language	English
Pages (from-to)	32-36
Number of pages	5
Journal	Cancer Research and Treatment
Volume	44
Issue number	1
DOIs	https://doi.org/10.4143/crt.2012.44.1.32
State	Published - Mar 2012

Keywords

Caspases
Colorectal neoplasms
Genetic polymorphism
Prognosis

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10.4143/crt.2012.44.1.32

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title = "Prognostic impact of polymorphisms in the CASPASE genes on survival of patients with colorectal cancer",

abstract = "Purpose This study analyzed potentially functional polymorphisms in CASPASE (CASP) genes and their impact on the prognosis for Korean colorectal cancer patients. Materials and Methods A total of 397 consecutive patients with curatively resected colorectal adenocarcinoma were enrolled in this study. Genomic DNA from these patients was extracted from fresh colorectal tissue, and the 10 polymorphisms in the CASP3, CASP6, CASP7, CASP8, CASP9, and CASP10 genes were determined using a reverse transcription polymerase chain reaction genotyping assay. Results The median patient age was 63 years, and 218 (54.9%) patients had colon cancer, while 179 (45.1%) patients had rectal cancer. Univariate and multivariate survival analysis including pathologic stage, patient age, differentiation, and carcinoembryonic antigen level demonstrated that these polymorphisms were not associated with either disease-free or overall survival. Conclusion None of the 10 polymorphisms in the CASP genes investigated in this study was found to be an independent prognostic marker for Korean patients with curatively resected colorectal cancer.",

keywords = "Caspases, Colorectal neoplasms, Genetic polymorphism, Prognosis",

author = "Choi, {Jun Young} and Kim, {Jong Gwang} and Lee, {You Jin} and Chae, {Yee Soo} and Sohn, {Sang Kyun} and Moon, {Joon Ho} and Kang, {Byung Woog} and Jung, {Min Kyu} and Jeon, {Seong Woo} and Park, {Jun Seok} and Choi, {Gyu Seog}",

year = "2012",

month = mar,

doi = "10.4143/crt.2012.44.1.32",

language = "English",

volume = "44",

pages = "32--36",

journal = "Cancer Research and Treatment",

issn = "1598-2998",

publisher = "Korean Cancer Association",

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TY - JOUR

T1 - Prognostic impact of polymorphisms in the CASPASE genes on survival of patients with colorectal cancer

AU - Choi, Jun Young

AU - Kim, Jong Gwang

AU - Lee, You Jin

AU - Chae, Yee Soo

AU - Sohn, Sang Kyun

AU - Moon, Joon Ho

AU - Kang, Byung Woog

AU - Jung, Min Kyu

AU - Jeon, Seong Woo

AU - Park, Jun Seok

AU - Choi, Gyu Seog

PY - 2012/3

Y1 - 2012/3

N2 - Purpose This study analyzed potentially functional polymorphisms in CASPASE (CASP) genes and their impact on the prognosis for Korean colorectal cancer patients. Materials and Methods A total of 397 consecutive patients with curatively resected colorectal adenocarcinoma were enrolled in this study. Genomic DNA from these patients was extracted from fresh colorectal tissue, and the 10 polymorphisms in the CASP3, CASP6, CASP7, CASP8, CASP9, and CASP10 genes were determined using a reverse transcription polymerase chain reaction genotyping assay. Results The median patient age was 63 years, and 218 (54.9%) patients had colon cancer, while 179 (45.1%) patients had rectal cancer. Univariate and multivariate survival analysis including pathologic stage, patient age, differentiation, and carcinoembryonic antigen level demonstrated that these polymorphisms were not associated with either disease-free or overall survival. Conclusion None of the 10 polymorphisms in the CASP genes investigated in this study was found to be an independent prognostic marker for Korean patients with curatively resected colorectal cancer.

AB - Purpose This study analyzed potentially functional polymorphisms in CASPASE (CASP) genes and their impact on the prognosis for Korean colorectal cancer patients. Materials and Methods A total of 397 consecutive patients with curatively resected colorectal adenocarcinoma were enrolled in this study. Genomic DNA from these patients was extracted from fresh colorectal tissue, and the 10 polymorphisms in the CASP3, CASP6, CASP7, CASP8, CASP9, and CASP10 genes were determined using a reverse transcription polymerase chain reaction genotyping assay. Results The median patient age was 63 years, and 218 (54.9%) patients had colon cancer, while 179 (45.1%) patients had rectal cancer. Univariate and multivariate survival analysis including pathologic stage, patient age, differentiation, and carcinoembryonic antigen level demonstrated that these polymorphisms were not associated with either disease-free or overall survival. Conclusion None of the 10 polymorphisms in the CASP genes investigated in this study was found to be an independent prognostic marker for Korean patients with curatively resected colorectal cancer.

KW - Caspases

KW - Colorectal neoplasms

KW - Genetic polymorphism

KW - Prognosis

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JO - Cancer Research and Treatment

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ER -

Prognostic impact of polymorphisms in the CASPASE genes on survival of patients with colorectal cancer

Abstract

Keywords

UN SDGs

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