Prognostic impact of tumor-associated macrophages on long-term oncologic outcomes in colorectal cancer

Hyeong Chan Shin; Incheol Seo; Hasong Jeong; Sang Jun Byun; Shin Kim; Sung Uk Bae; Sun Young Kwon; Hye Won Lee

doi:10.3390/life11111240

Prognostic impact of tumor-associated macrophages on long-term oncologic outcomes in colorectal cancer

Hyeong Chan Shin
, Incheol Seo
, Hasong Jeong
, Sang Jun Byun
, Shin Kim
, Sung Uk Bae
, Sun Young Kwon
, Hye Won Lee

Department of Medicine

Keimyung University

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

This study evaluated the correlation between tumor-associated macrophages (TAMs) and long-term oncologic outcomes in colorectal cancer (CRC). We evaluated TAMs based on the expression of CD68, CD11c, and CD163 as optimal markers via immunohistochemistry in 148 patients with CRC who underwent surgical resection between September 1999 and August 2004. A high proportion of CD68-positive macrophages were associated with the occurrence of distant metastasis. A low proportion of CD11c-positive macrophages were associated with unfavorable overall survival (OS) and disease-free survival. CD11c-positive macrophages were found to act as independent prognostic factors for OS. An analysis of our long-term data indicated that TAMs are significantly associated with OS and prognosis in CRC.

Original language	English
Article number	1240
Journal	Life
Volume	11
Issue number	11
DOIs	https://doi.org/10.3390/life11111240
State	Published - Nov 2021

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Colorectal cancer
Prognosis
Tumor microenvironment
Tumor-associated macrophages

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10.3390/life11111240

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title = "Prognostic impact of tumor-associated macrophages on long-term oncologic outcomes in colorectal cancer",

abstract = "This study evaluated the correlation between tumor-associated macrophages (TAMs) and long-term oncologic outcomes in colorectal cancer (CRC). We evaluated TAMs based on the expression of CD68, CD11c, and CD163 as optimal markers via immunohistochemistry in 148 patients with CRC who underwent surgical resection between September 1999 and August 2004. A high proportion of CD68-positive macrophages were associated with the occurrence of distant metastasis. A low proportion of CD11c-positive macrophages were associated with unfavorable overall survival (OS) and disease-free survival. CD11c-positive macrophages were found to act as independent prognostic factors for OS. An analysis of our long-term data indicated that TAMs are significantly associated with OS and prognosis in CRC.",

keywords = "Colorectal cancer, Prognosis, Tumor microenvironment, Tumor-associated macrophages",

author = "Shin, \{Hyeong Chan\} and Incheol Seo and Hasong Jeong and Byun, \{Sang Jun\} and Shin Kim and Bae, \{Sung Uk\} and Kwon, \{Sun Young\} and Lee, \{Hye Won\}",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = nov,

doi = "10.3390/life11111240",

language = "English",

volume = "11",

journal = "Life",

issn = "2075-1729",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

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TY - JOUR

T1 - Prognostic impact of tumor-associated macrophages on long-term oncologic outcomes in colorectal cancer

AU - Shin, Hyeong Chan

AU - Seo, Incheol

AU - Jeong, Hasong

AU - Byun, Sang Jun

AU - Kim, Shin

AU - Bae, Sung Uk

AU - Kwon, Sun Young

AU - Lee, Hye Won

PY - 2021/11

Y1 - 2021/11

N2 - This study evaluated the correlation between tumor-associated macrophages (TAMs) and long-term oncologic outcomes in colorectal cancer (CRC). We evaluated TAMs based on the expression of CD68, CD11c, and CD163 as optimal markers via immunohistochemistry in 148 patients with CRC who underwent surgical resection between September 1999 and August 2004. A high proportion of CD68-positive macrophages were associated with the occurrence of distant metastasis. A low proportion of CD11c-positive macrophages were associated with unfavorable overall survival (OS) and disease-free survival. CD11c-positive macrophages were found to act as independent prognostic factors for OS. An analysis of our long-term data indicated that TAMs are significantly associated with OS and prognosis in CRC.

AB - This study evaluated the correlation between tumor-associated macrophages (TAMs) and long-term oncologic outcomes in colorectal cancer (CRC). We evaluated TAMs based on the expression of CD68, CD11c, and CD163 as optimal markers via immunohistochemistry in 148 patients with CRC who underwent surgical resection between September 1999 and August 2004. A high proportion of CD68-positive macrophages were associated with the occurrence of distant metastasis. A low proportion of CD11c-positive macrophages were associated with unfavorable overall survival (OS) and disease-free survival. CD11c-positive macrophages were found to act as independent prognostic factors for OS. An analysis of our long-term data indicated that TAMs are significantly associated with OS and prognosis in CRC.

KW - Colorectal cancer

KW - Prognosis

KW - Tumor microenvironment

KW - Tumor-associated macrophages

UR - https://www.scopus.com/pages/publications/85119669035

U2 - 10.3390/life11111240

DO - 10.3390/life11111240

M3 - Article

AN - SCOPUS:85119669035

SN - 2075-1729

VL - 11

JO - Life

JF - Life

IS - 11

M1 - 1240

ER -

Prognostic impact of tumor-associated macrophages on long-term oncologic outcomes in colorectal cancer

Abstract

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Keywords

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