Prognostic value of telomeric zinc finger-associated protein expression in adenocarcinoma and squamous cell carcinoma of lung

Gun Jik Kim, Jae Ho Lee, Mincheol Chae, Deok Heon Lee

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Background and Objectives: Telomeric zinc finger-associated protein (TZAP) is a telomere regulation protein, previously known as ZBTB48. It binds preferentially to elongated telomeres, competing with telomeric repeat factors 1 and 2. TZAP expression may be associated with carcinogenesis, however; this study has not yet been performed in lung cancer. In this study, we examined the clinicopathological and prognostic values of TZAP expression in non-small cell lung cancer (NSCLC). Materials and Methods: Data were collected from The Cancer Genome Atlas. The clinical and prognostic values of TZAP for NSCLC were examined in adenocarcinoma (AD) and squamous cell carcinoma (SCC). Results: TZAP expression significantly increased in NSCLC tissues compared with normal tissues. In AD, TZAP expression was lower in patients with higher T stage (p = 0.005), and was associated with lymph node stage in SCC (p = 0.005). Survival analysis showed shorter disease-free survival in AD patients with lower TZAP expression (p = 0.047). TZAP expression did not have other clinical or prognostic value for AD and SCC. Conclusions: TZAP expression is a potential prognostic marker for NSCLC, especially in patients with AD.

Original languageEnglish
Article number1223
JournalMedicina (Lithuania)
Volume57
Issue number11
DOIs
StatePublished - Nov 2021

Keywords

  • Lung cancer
  • Telomere
  • TZAP
  • ZBTB48

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