TY - JOUR
T1 - Proinflammatory cytokine expression in the lung of pigs with porcine circovirus type 2-associated respiratory disease
AU - Chae, Joon Seok
AU - Choi, Kyoung Seong
PY - 2011/4
Y1 - 2011/4
N2 - Porcine circovirus type 2 (PCV2) causes a significant health problem for the swine industry worldwide. In this study, we investigated the cytokine expression profiles (IFN-γ, IL-1α, IL-8, and IL-10) in the lungs of pigs with PCV2-associated respiratory disease. The mRNA expressions of IL-1α and IL-8 were significantly up-regulated in pigs with PCV2-associated respiratory disease, while IL-10 expression was not detected. These results suggest that the increased expressions of proinflammatory cytokines in the lungs may play an important role in the immunopathologic response in pigs with PCV2-associated respiratory disease.
AB - Porcine circovirus type 2 (PCV2) causes a significant health problem for the swine industry worldwide. In this study, we investigated the cytokine expression profiles (IFN-γ, IL-1α, IL-8, and IL-10) in the lungs of pigs with PCV2-associated respiratory disease. The mRNA expressions of IL-1α and IL-8 were significantly up-regulated in pigs with PCV2-associated respiratory disease, while IL-10 expression was not detected. These results suggest that the increased expressions of proinflammatory cytokines in the lungs may play an important role in the immunopathologic response in pigs with PCV2-associated respiratory disease.
KW - PCV2-associated respiratory disease
KW - Porcine circovirus type 2 (PCV2)
KW - Proinflammatory cytokines
UR - http://www.scopus.com/inward/record.url?scp=79951773447&partnerID=8YFLogxK
U2 - 10.1016/j.rvsc.2010.05.024
DO - 10.1016/j.rvsc.2010.05.024
M3 - Article
C2 - 20542307
AN - SCOPUS:79951773447
SN - 0034-5288
VL - 90
SP - 321
EP - 323
JO - Research in Veterinary Science
JF - Research in Veterinary Science
IS - 2
ER -