Proinflammatory cytokine expression in the lung of pigs with porcine circovirus type 2-associated respiratory disease

Joon Seok Chae; Kyoung Seong Choi

doi:10.1016/j.rvsc.2010.05.024

Proinflammatory cytokine expression in the lung of pigs with porcine circovirus type 2-associated respiratory disease

Joon Seok Chae
, Kyoung Seong Choi

Seoul National University

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Porcine circovirus type 2 (PCV2) causes a significant health problem for the swine industry worldwide. In this study, we investigated the cytokine expression profiles (IFN-γ, IL-1α, IL-8, and IL-10) in the lungs of pigs with PCV2-associated respiratory disease. The mRNA expressions of IL-1α and IL-8 were significantly up-regulated in pigs with PCV2-associated respiratory disease, while IL-10 expression was not detected. These results suggest that the increased expressions of proinflammatory cytokines in the lungs may play an important role in the immunopathologic response in pigs with PCV2-associated respiratory disease.

Original language	English
Pages (from-to)	321-323
Number of pages	3
Journal	Research in Veterinary Science
Volume	90
Issue number	2
DOIs	https://doi.org/10.1016/j.rvsc.2010.05.024
State	Published - Apr 2011

Keywords

PCV2-associated respiratory disease
Porcine circovirus type 2 (PCV2)
Proinflammatory cytokines

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10.1016/j.rvsc.2010.05.024

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title = "Proinflammatory cytokine expression in the lung of pigs with porcine circovirus type 2-associated respiratory disease",

abstract = "Porcine circovirus type 2 (PCV2) causes a significant health problem for the swine industry worldwide. In this study, we investigated the cytokine expression profiles (IFN-γ, IL-1α, IL-8, and IL-10) in the lungs of pigs with PCV2-associated respiratory disease. The mRNA expressions of IL-1α and IL-8 were significantly up-regulated in pigs with PCV2-associated respiratory disease, while IL-10 expression was not detected. These results suggest that the increased expressions of proinflammatory cytokines in the lungs may play an important role in the immunopathologic response in pigs with PCV2-associated respiratory disease.",

keywords = "PCV2-associated respiratory disease, Porcine circovirus type 2 (PCV2), Proinflammatory cytokines",

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AU - Chae, Joon Seok

AU - Choi, Kyoung Seong

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N2 - Porcine circovirus type 2 (PCV2) causes a significant health problem for the swine industry worldwide. In this study, we investigated the cytokine expression profiles (IFN-γ, IL-1α, IL-8, and IL-10) in the lungs of pigs with PCV2-associated respiratory disease. The mRNA expressions of IL-1α and IL-8 were significantly up-regulated in pigs with PCV2-associated respiratory disease, while IL-10 expression was not detected. These results suggest that the increased expressions of proinflammatory cytokines in the lungs may play an important role in the immunopathologic response in pigs with PCV2-associated respiratory disease.

AB - Porcine circovirus type 2 (PCV2) causes a significant health problem for the swine industry worldwide. In this study, we investigated the cytokine expression profiles (IFN-γ, IL-1α, IL-8, and IL-10) in the lungs of pigs with PCV2-associated respiratory disease. The mRNA expressions of IL-1α and IL-8 were significantly up-regulated in pigs with PCV2-associated respiratory disease, while IL-10 expression was not detected. These results suggest that the increased expressions of proinflammatory cytokines in the lungs may play an important role in the immunopathologic response in pigs with PCV2-associated respiratory disease.

KW - PCV2-associated respiratory disease

KW - Porcine circovirus type 2 (PCV2)

KW - Proinflammatory cytokines

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ER -

Proinflammatory cytokine expression in the lung of pigs with porcine circovirus type 2-associated respiratory disease

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