Promoting bone regeneration by 3D-printed poly(glycolic acid)/hydroxyapatite composite scaffolds

Taegyun Yeo; Young Gwang Ko; Eun Jin Kim; Oh Kyoung Kwon; Ho Yun Chung; Oh Hyeong Kwon

doi:10.1016/j.jiec.2020.11.004

Promoting bone regeneration by 3D-printed poly(glycolic acid)/hydroxyapatite composite scaffolds

Taegyun Yeo, Young Gwang Ko, Eun Jin Kim, Oh Kyoung Kwon, Ho Yun Chung, Oh Hyeong Kwon

Department of Medicine

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

Hydroxyapatite (HAp) is a major bone graft component for hard tissue regeneration. However, sintered HAp has poor formability and mechanical properties. Porous 3D scaffolds for bone tissue regeneration were printed with computer-aided modeling using poly(glycolic acid) (PGA) and HAp. PGA scaffolds containing HAp nanoparticles were fabricated with a 400 μm pore size. PGA/HAp scaffolds containing 12.5 wt% HAp showed considerable compressive strength, osteogenesis, mineralization, and biodegradation. In in vivo animal experiments, the PGA/HAp group exhibited 47% bone regeneration, with superior bone mineral density 8 weeks after surgery. 3D-printed PGA/HAp scaffolds could provide a feasible option to promote patient-specific bone regeneration.

Original language	English
Pages (from-to)	343-351
Number of pages	9
Journal	Journal of Industrial and Engineering Chemistry
Volume	94
DOIs	https://doi.org/10.1016/j.jiec.2020.11.004
State	Published - 25 Feb 2021

Keywords

3D printing
Hydroxyapatite
Poly(glycolic acid)
Scaffold
Tissue engineering

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10.1016/j.jiec.2020.11.004

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title = "Promoting bone regeneration by 3D-printed poly(glycolic acid)/hydroxyapatite composite scaffolds",

abstract = "Hydroxyapatite (HAp) is a major bone graft component for hard tissue regeneration. However, sintered HAp has poor formability and mechanical properties. Porous 3D scaffolds for bone tissue regeneration were printed with computer-aided modeling using poly(glycolic acid) (PGA) and HAp. PGA scaffolds containing HAp nanoparticles were fabricated with a 400 μm pore size. PGA/HAp scaffolds containing 12.5 wt% HAp showed considerable compressive strength, osteogenesis, mineralization, and biodegradation. In in vivo animal experiments, the PGA/HAp group exhibited 47% bone regeneration, with superior bone mineral density 8 weeks after surgery. 3D-printed PGA/HAp scaffolds could provide a feasible option to promote patient-specific bone regeneration.",

keywords = "3D printing, Hydroxyapatite, Poly(glycolic acid), Scaffold, Tissue engineering",

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AU - Yeo, Taegyun

AU - Ko, Young Gwang

AU - Kim, Eun Jin

AU - Kwon, Oh Kyoung

AU - Chung, Ho Yun

AU - Kwon, Oh Hyeong

PY - 2021/2/25

Y1 - 2021/2/25

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AB - Hydroxyapatite (HAp) is a major bone graft component for hard tissue regeneration. However, sintered HAp has poor formability and mechanical properties. Porous 3D scaffolds for bone tissue regeneration were printed with computer-aided modeling using poly(glycolic acid) (PGA) and HAp. PGA scaffolds containing HAp nanoparticles were fabricated with a 400 μm pore size. PGA/HAp scaffolds containing 12.5 wt% HAp showed considerable compressive strength, osteogenesis, mineralization, and biodegradation. In in vivo animal experiments, the PGA/HAp group exhibited 47% bone regeneration, with superior bone mineral density 8 weeks after surgery. 3D-printed PGA/HAp scaffolds could provide a feasible option to promote patient-specific bone regeneration.

KW - 3D printing

KW - Hydroxyapatite

KW - Poly(glycolic acid)

KW - Scaffold

KW - Tissue engineering

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Promoting bone regeneration by 3D-printed poly(glycolic acid)/hydroxyapatite composite scaffolds

Abstract

Keywords

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