TY - JOUR
T1 - Promotion effect of constituents from the root of Polygonum multiflorum on hair growth
AU - Sun, Ya Nan
AU - Cui, Long
AU - Li, Wei
AU - Yan, Xi Tao
AU - Yang, Seo Young
AU - Kang, Jung Il
AU - Kang, Hee Kyoung
AU - Kim, Young Ho
PY - 2013/9/1
Y1 - 2013/9/1
N2 - Two new compounds, gallic acid ester of torachrysone-8-O-β-d-glucoside (1) and (E)-2,3,5,4′-tetrahydroxystilbene-2-O-β-d-xyloside (4), along with eight known compounds (2, 3, 5-10) were isolated from a 70% ethanol extract of Polygonum multiflorum roots. The structures were determined by 1H and 13C NMR, HMQC, and HMBC spectrometry. Extracts of P. multiflorum have been reported to promote hair growth in vivo. This study was carried out to evaluate the effects of isolated compounds from P. multiflorum on promoting hair growth using dermal papilla cells (DPCs), which play an important role in hair growth. When DPCs were treated with compounds (1-10) from P. multiflorum, compounds 1, 2, 3, 6, and 10 increased the proliferation of DPCs compared with the control. Specifically, compound 2 (10 and 20 μM) induced a greater increase in the proliferation of DPCs than minoxidil (10 μM). Additionally, treatment of vibrissa follicles with compound 2 for 21 days increased hair-fiber length significantly. On the basis of this result, further investigation and optimization of these derivatives might help in the development of therapeutic agents for the treatment of alopecia.
AB - Two new compounds, gallic acid ester of torachrysone-8-O-β-d-glucoside (1) and (E)-2,3,5,4′-tetrahydroxystilbene-2-O-β-d-xyloside (4), along with eight known compounds (2, 3, 5-10) were isolated from a 70% ethanol extract of Polygonum multiflorum roots. The structures were determined by 1H and 13C NMR, HMQC, and HMBC spectrometry. Extracts of P. multiflorum have been reported to promote hair growth in vivo. This study was carried out to evaluate the effects of isolated compounds from P. multiflorum on promoting hair growth using dermal papilla cells (DPCs), which play an important role in hair growth. When DPCs were treated with compounds (1-10) from P. multiflorum, compounds 1, 2, 3, 6, and 10 increased the proliferation of DPCs compared with the control. Specifically, compound 2 (10 and 20 μM) induced a greater increase in the proliferation of DPCs than minoxidil (10 μM). Additionally, treatment of vibrissa follicles with compound 2 for 21 days increased hair-fiber length significantly. On the basis of this result, further investigation and optimization of these derivatives might help in the development of therapeutic agents for the treatment of alopecia.
KW - Dermal papilla cells (DPCs)
KW - Hair growth
KW - Hair-fiber length
KW - Polygonum multiflorum
UR - http://www.scopus.com/inward/record.url?scp=84881373855&partnerID=8YFLogxK
U2 - 10.1016/j.bmcl.2013.06.098
DO - 10.1016/j.bmcl.2013.06.098
M3 - Article
C2 - 23896496
AN - SCOPUS:84881373855
SN - 0960-894X
VL - 23
SP - 4801
EP - 4805
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 17
ER -