Protective association of HLA-DRB1*13:02, HLA-DRB1*04:06, and HLA-DQB1*06:04 alleles with cervical cancer in a Korean population

Hyoeun Shim; Boram Park; Hye Jin Shin; Jungnam Joo; Kyong Ah Yoon; Young Min Kim; Tomonori Hayashi; Katsushi Tokunaga; Sun Young Kong; Joo Young Kim

doi:10.1016/j.humimm.2018.10.013

Protective association of HLA-DRB113:02, HLA-DRB104:06, and HLA-DQB1*06:04 alleles with cervical cancer in a Korean population

Hyoeun Shim, Boram Park, Hye Jin Shin, Jungnam Joo, Kyong Ah Yoon, Young Min Kim, Tomonori Hayashi, Katsushi Tokunaga, Sun Young Kong, Joo Young Kim

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Human leukocyte antigen (HLA) class II alleles have been previously associated with cervical cancer. However, these associations vary widely across racial and ethnic groups. Therefore, we evaluated the effect of HLA class II alleles on cervical cancer in a Korean population. HLA-DRB1, HLA-DQB1, and HLA-DQA1 alleles were analyzed in 457 cervical cancer patients and compared to those of 926 control subjects. The odds ratio (OR) of each allele between the patients and controls was calculated using the logistic regression model. Patients, had significantly lower frequencies of HLA-DRB1 and HLA-DQB1 alleles than control subjects: HLA-DRB1*13:02:01 (4.4% vs 8.8%; OR 0.48, 95% confidence interval (CI) 0.27–0.84; p = 0.001), HLA-DRB1*04:06 (2.1% vs 4.7%; OR 0.44, 95% CI 0.20–0.97; p = 0.033), and HLA-DQB1*06:04:01 (2.3% vs 5.0%; OR 0.46, 95% CI 0.22–0.94; p = 0.021). No significant association was observed for HLA-DQA1.

Original language	English
Pages (from-to)	107-111
Number of pages	5
Journal	Human Immunology
Volume	80
Issue number	2
DOIs	https://doi.org/10.1016/j.humimm.2018.10.013
State	Published - Feb 2019

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@article{76c0e469806b45d6bf0cabb71f68d249,

title = "Protective association of HLA-DRB1*13:02, HLA-DRB1*04:06, and HLA-DQB1*06:04 alleles with cervical cancer in a Korean population",

abstract = "Human leukocyte antigen (HLA) class II alleles have been previously associated with cervical cancer. However, these associations vary widely across racial and ethnic groups. Therefore, we evaluated the effect of HLA class II alleles on cervical cancer in a Korean population. HLA-DRB1, HLA-DQB1, and HLA-DQA1 alleles were analyzed in 457 cervical cancer patients and compared to those of 926 control subjects. The odds ratio (OR) of each allele between the patients and controls was calculated using the logistic regression model. Patients, had significantly lower frequencies of HLA-DRB1 and HLA-DQB1 alleles than control subjects: HLA-DRB1*13:02:01 (4.4% vs 8.8%; OR 0.48, 95% confidence interval (CI) 0.27–0.84; p = 0.001), HLA-DRB1*04:06 (2.1% vs 4.7%; OR 0.44, 95% CI 0.20–0.97; p = 0.033), and HLA-DQB1*06:04:01 (2.3% vs 5.0%; OR 0.46, 95% CI 0.22–0.94; p = 0.021). No significant association was observed for HLA-DQA1.",

author = "Hyoeun Shim and Boram Park and Shin, {Hye Jin} and Jungnam Joo and Yoon, {Kyong Ah} and Kim, {Young Min} and Tomonori Hayashi and Katsushi Tokunaga and Kong, {Sun Young} and Kim, {Joo Young}",

note = "Publisher Copyright: {\textcopyright} 2018",

year = "2019",

month = feb,

doi = "10.1016/j.humimm.2018.10.013",

language = "English",

volume = "80",

pages = "107--111",

journal = "Human Immunology",

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T1 - Protective association of HLA-DRB1*13:02, HLA-DRB1*04:06, and HLA-DQB1*06:04 alleles with cervical cancer in a Korean population

AU - Shim, Hyoeun

AU - Park, Boram

AU - Shin, Hye Jin

AU - Joo, Jungnam

AU - Yoon, Kyong Ah

AU - Kim, Young Min

AU - Hayashi, Tomonori

AU - Tokunaga, Katsushi

AU - Kong, Sun Young

AU - Kim, Joo Young

PY - 2019/2

Y1 - 2019/2

N2 - Human leukocyte antigen (HLA) class II alleles have been previously associated with cervical cancer. However, these associations vary widely across racial and ethnic groups. Therefore, we evaluated the effect of HLA class II alleles on cervical cancer in a Korean population. HLA-DRB1, HLA-DQB1, and HLA-DQA1 alleles were analyzed in 457 cervical cancer patients and compared to those of 926 control subjects. The odds ratio (OR) of each allele between the patients and controls was calculated using the logistic regression model. Patients, had significantly lower frequencies of HLA-DRB1 and HLA-DQB1 alleles than control subjects: HLA-DRB1*13:02:01 (4.4% vs 8.8%; OR 0.48, 95% confidence interval (CI) 0.27–0.84; p = 0.001), HLA-DRB1*04:06 (2.1% vs 4.7%; OR 0.44, 95% CI 0.20–0.97; p = 0.033), and HLA-DQB1*06:04:01 (2.3% vs 5.0%; OR 0.46, 95% CI 0.22–0.94; p = 0.021). No significant association was observed for HLA-DQA1.

AB - Human leukocyte antigen (HLA) class II alleles have been previously associated with cervical cancer. However, these associations vary widely across racial and ethnic groups. Therefore, we evaluated the effect of HLA class II alleles on cervical cancer in a Korean population. HLA-DRB1, HLA-DQB1, and HLA-DQA1 alleles were analyzed in 457 cervical cancer patients and compared to those of 926 control subjects. The odds ratio (OR) of each allele between the patients and controls was calculated using the logistic regression model. Patients, had significantly lower frequencies of HLA-DRB1 and HLA-DQB1 alleles than control subjects: HLA-DRB1*13:02:01 (4.4% vs 8.8%; OR 0.48, 95% confidence interval (CI) 0.27–0.84; p = 0.001), HLA-DRB1*04:06 (2.1% vs 4.7%; OR 0.44, 95% CI 0.20–0.97; p = 0.033), and HLA-DQB1*06:04:01 (2.3% vs 5.0%; OR 0.46, 95% CI 0.22–0.94; p = 0.021). No significant association was observed for HLA-DQA1.

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U2 - 10.1016/j.humimm.2018.10.013

DO - 10.1016/j.humimm.2018.10.013

M3 - Article

C2 - 30352277

AN - SCOPUS:85057293829

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VL - 80

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JO - Human Immunology

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IS - 2

ER -

Protective association of HLA-DRB113:02, HLA-DRB104:06, and HLA-DQB1*06:04 alleles with cervical cancer in a Korean population

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